Latest News Releases 12 April

A new study cracks the code for increasing sustainability of the pest-killing proteins in genetically engineered crops.

Cell therapy, a treatment that involves transferring living cells into a patient to help restore function or fight disease, shows great potential for treating diseases such as cancers, inflammatory diseases, and chronic degenerative disorders. However, a critical and long-standing challenge faced in the manufacturing of cell therapy products (CTPs) is ensuring that cells are contamination-free before patient use, with serious implications for patients who often need rapid access to potentially life-saving therapies.

Researchers from the Critical Analytics for Manufacturing Personalized-Medicine (CAMP), interdisciplinary research group (IRG) of Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Massachusetts Institute of Technology (MIT), A*STAR Skin Research Labs (A*SRL), and National University of Singapore (NUS), have developed a novel method that can quickly and automatically detect microbial contamination in CTPs early on during the manufacturing process to implement timely corrective actions.

This method analyses light absorption patterns using machine learning and ultraviolet light to provide an intuitive, rapid "yes/no" contamination assessment. It offers significant advantages over traditional sterility tests, including a faster contamination detection period, a simpler workflow with no additional preparation required, reduced manpower requirements, and lower costs.

Future research aims to broaden the application across a wider range of microbial contaminants and test the model's robustness across more cell types. Beyond cell therapy manufacturing, this method can also be applied to the food & beverage industry as part of microbial quality control testing to ensure food products meet safety standards.

An Edith Cowan University (ECU) study has found children born to mothers who experienced gestational diabetes (GDM) during pregnancy are more likely to develop attention-deficient hyperactive disorder (ADHD) and externalising behaviour.  

A newly-published Cochrane review reveals significant gaps in the clinical rating scales used to assess pain in newborn babies, highlighting the urgent need for improved tools and global collaboration.

The powerful potential of nano technologies and AI to detect oral cancer earlier and more accurately have been revealed by a University of Otago – Ōtākou Whakaihu Waka study.

https://doi.org/10.1016/j.apsb.2025.02.009

This new article publication from Acta Pharmaceutica Sinica B, discusses establishment of interpretable cytotoxicity prediction models using machine learning analysis of transcriptome features.

https://doi.org/10.1016/j.apsb.2024.12.018

This new article publication from Acta Pharmaceutica Sinica B, discusses how disrupting calcium homeostasis and glycometabolism in engineered lipid-based pharmaceuticals propel cancer immunogenic death.