Hereditary spherocytosis (HS) and thalassemia are among the most common inherited hemolytic anemias, yet their co-occurrence presents unique diagnostic challenges due to overlapping clinical manifestations. This case report describes a unique presentation of concurrent hematological disorders in a 2-year-old Chinese boy: hereditary spherocytosis caused by a novel gene mutation, together with α-globin gene triplication. The child presented with a history of longstanding hemolytic disease, with recurrent episodes of anemia, jaundice, and abdominal pain triggered by upper respiratory infections, accompanied by splenomegaly and cholecystolithiasis. Laboratory evaluation revealed increased osmotic fragility of red blood cells and elevated reticulocyte count, supporting a diagnosis of hemolytic anemia. Mutation analysis identified a de novo heterozygous mutation in the SPTB gene: c.149-1G>A, a novel splicing mutation not detected in either parent and not previously reported in the literature. This pathogenic variant is speculated to affect pre-mRNA splicing of β-spectrin, a critical component of the erythrocyte cytoskeleton. Concurrently, the child was found to carry α-globin gene triplication (αααanti4.2), a relatively rare numerical variation that may complicate the clinical presentation by altering hemoglobin synthesis.

For the first time, researchers have discovered a single gene that simultaneously controls both the sourness and the colour of citrus fruit. 

Plants of the Panax genus—which includes ginseng and notoginseng—are known to suppress the growth of neighbouring plants through chemical warfare, but the precise molecular weapons and their targets have remained unclear. 

Grape aroma is shaped not only by the volatile compounds we can smell but also by their non‑volatile, sugar‑bound counterparts—flavour precursors locked away until fermentation releases them. 

For centuries, Epimedium has been used in traditional medicine to support bone health and vitality, yet the precise location of its active compounds within the plant—and the enzymes that create them—has remained a mystery. 

Accurate water quality forecasting is essential for protecting aquatic ecosystems and securing global water supplies, yet traditional models often struggle with the complex, nonlinear dynamics of algal blooms. 

Fruit firmness is usually treated as a trait that is lost during ripening, but new evidence shows that part of the story begins much earlier, while the fruit is still building its structure. 

Photocatalytic reactions can be driven by both photochemical and photothermal processes. However, their individual contributions and synergistic effect remain to be clarified. Herein, we investigated the respective roles of these effects using a Cu–TiO₂/Ti model catalyst that integrated photochemical and photothermal functionalities within a single photocatalytic system. Employing photocatalytic methanol decomposition as a model reaction, the Cu–TiO₂/Ti catalyst achieved a high H₂ yield rate of 0.511 mmol h⁻¹ with selectivity of 96.6% toward HCHO among oxidation products, attributed to the cooperative action of photochemical and photothermal processes. In situ resonant Auger electron spectroscopy (RAS), together with in situ Cu K-edge X-ray absorption fine structure and excited-state density functional theory calculations, revealed the accumulation of photogenerated electrons at Cu sites from TiO₂, suggests the possible formation of an electron transfer pathway from TiO₂ to Cu, which promotes stepwise methanol dehydrogenation to HCHO and H₂. Simultaneously, the photothermal contribution from Ti enhanced catalytic activity by accelerating reaction kinetics and promoting the desorption of HCHO, thereby suppressing its overoxidation to CO.

Microplastics are often viewed as pollutants in their own right, but their environmental impact may extend far beyond the plastic particles themselves. A new review shows that microplastics can act as mobile "pollutant shuttles," carrying toxic chemicals, microorganisms and antibiotic resistance genes through water, soil, food webs and even across environmental boundaries.