Uncovering the dynamics of sugar–protein interactions
Peer-Reviewed Publication
Updates every hour. Last Updated: 9-Dec-2025 19:11 ET (10-Dec-2025 00:11 GMT/UTC)
Polydopamine-coated magnetic liposomes offer insight into the lectin–glycan interactions in motion. By observing minute changes in the rotational motion of magnetic nanoparticles under alternating magnetic field, the technique reveals binding patterns, including strong multivalent binding events under natural and physiological conditions. The findings of this study emphasize the role of structure–property relationships, while designing magnetic liposome-based biorecognition systems. This approach could accelerate innovations in diagnostics, glycoscience research, and drug discovery.
Biological supramolecular structures exhibit both lateral and longitudinal interactions, rendering the structure responsive to changes. Thus far, lateral interactions of synthetically assembled supramolecular polymers have only been elucidated. Inspired by microtubules, this study reports cooperative self-assembly of aryl barbiturate molecules into helical coils, driven by the concerted action of noncovalent lateral and longitudinal interactions. These synthetic polymers uniquely alter with changes in temperature. This conceptual advancement will influence future material designs of next-generation polymers.
Researchers from The University of Osaka found migration of glucose and fructose from the blood to saliva drives oral microbiome dysbiosis in patients with type 2 diabetes, increasing the development of dental caries. This suggests that glycemic control could be an effective strategy for controlling dental caries in this population.
Salt stress is a major factor that impairs plant growth and yield. In a breakthrough, researchers from Waseda University have revealed that Arabidopsis thaliana myosin XI-1—a member of the motor protein myosin XI—significantly regulates adaptation to salt stress via intracellular sodium ion (Na⁺) homeostasis. It can thus serve as a promising molecular target for the development of salt-tolerant crops, contributing to sustainable farming in saline-affected regions.