>Solving the problem of mRNA-loaded lipid nanoparticles accumulating in the liver and causing unintended expression of pharmacologically active proteins

>By coating the walls of intrahepatic capillaries (liver sinusoidal walls), the accumulation of lipid nanoparticles in the liver is prevented (demonstrated in animal studies)

>Improved efficacy and safety in infectious prevention vaccines, cancer treatment vaccines, and cytokine therapies

>Substances with established clinical safety profiles are used as coating agents (enabling rapid clinical trials)

>Published online in ACS Nano: http://doi.org/10.1021/acsnano.6c08403

A team led by researchers from the University of Osaka has used acoustic tweezers to analyze the mechanical properties of biopolymer droplets without needing to physically touch the material. Using this method, the team investigated the stiffness of condensates of a model biopolymer. This technique will further the knowledge of biopolymer droplets and their roles in cellular biology, and may lead to the discovery of novel methods of treating diseases caused by the dysfunction of these droplets.

Kyoto, Japan -- Massive storms like the 2005 Hurricane Katrina, that cause over $100 billion in damage, were once considered once-in-a-lifetime events. Increasingly, however, they are becoming the norm: a direct result of climate change, which has made large storms more frequent, intense, and slower-moving, deepening their impact.

Hurricanes can damage homes through flooding and strong winds, and insurance claims target both. After the 2022 Hurricane Ian, for example, 44 percent of insurance claims were for flooding and 56 percent were for wind damage. Yet most economic research focuses on flooding because elevation data and hydrological models can predict flood extent, whereas identifying the location and severity of wind damage across a wide area has posed a particular challenge.

Unlike flooding, there is nothing like a dam or levee that can shield an entire community from wind, so the responsibility falls almost entirely on individual homeowners. To mitigate wind damage, Florida enacted the 2001 Florida Building Code -- 2001 FBC -- which required new and re-roofed homes to use stronger roof-to-wall connections, thicker roof decking, and even impact-resistant windows and doors in some areas. Many homeowners had to spend thousands of dollars to reinforce a roof or install impact-resistant features, yet whether these preventative measures proved to be worth the average cost of about $4,930 had remained unclear.

Kyoto, Japan -- Close to a phase transition, very different materials can follow the same mathematical rules. The concept of universality, which groups seemingly distinct systems based on their common properties, was developed to describe this phenomenon. In magnetic systems, ferromagnets, ferrimagnets, and antiferromagnets fall into the same universality class when short-range interactions dominate and their spatial and spin dimensionalities coincide. However, this universality has not been established when long-range interactions dominate.

In insulating magnets, long-range coupling may originate from dipole-dipole interactions. However, dipolar-driven mean-field criticality has only been firmly established in ferromagnets, leaving the ferrimagnetic and antiferromagnetic cases unexplored. A collaborative team of researchers from Kyoto University, Tohoku University, and the Australian Nuclear Science and Technology Organisation (ANSTO), set out to bridge this gap.

"Near a phase transition, the microscopically strongest interaction is not always the one that sets the critical rules," explains corresponding author Yusuke Nambu. "Exchange interactions build the ferrimagnetic state, but because dipolar interactions reach much farther, they determine how the material approaches the transition."

Ryonosuke Akimoto, a graduate student at The University of Tokyo (who conducted this research at Aoyama Gakuin University), and Associate Professor Yuji Ogihara at Aoyama Gakuin University have revealed that the extraversion of Japanese people declined from 2010 to 2021 (Figure 1).

In Japanese media and social commentary, it has frequently been pointed out that Japanese people are becoming more "inward-looking." However, the extent to which it reflects an actual psychological shift in personality traits among the Japanese population has not been adequately examined. Therefore, an empirical examination was required.

In this study, we comprehensively collected previous research that measured the extraversion of Japanese participants. We statistically controlled for attributes such as participants' age and gender, and analyzed the trends over a 12-year period.

As a result, it became clear that the extraversion of Japanese people has consistently declined in recent years. This downward trend occurred equally in both men and women, and the extent of change was similar between them. Furthermore, we conducted an analysis limited to data up to 2019 to account for the impact of the COVID-19 pandemic. This analysis also confirmed a similar decline. These findings provide empirical evidence for the long-standing discourse of an "inward-looking" trend among Japanese people.

Finding new species in unassuming settings brings light to further exploration and conservation efforts to preserve the unique diversity in groundwater environments

Histone variants help establish DNA methylation at transposons (jumping genes) while preventing this epigenetic modification from spreading to essential genes in plants, reveals a study from Institute of Science Tokyo. By revealing how these chromosome-associated proteins guide the formation of precise epigenomic patterns, the findings provide new insights into the selective silencing of transposons, laying the groundwork for future epigenome-editing technologies for crop improvement and disease research.