3 million cells per minute: parallel microdevice with AI-powered single-cell analysis
Peer-Reviewed Publication
Updates every hour. Last Updated: 29-Dec-2025 22:12 ET (30-Dec-2025 03:12 GMT/UTC)
Many applications—from drug discovery and diagnostics to cell engineering and gene modulation—require delivering biomolecules into large numbers of cells and rapidly evaluating the outcomes. The challenge is twofold: achieve intracellular delivery at scale across diverse cells and cargos, and obtain quantitative results fast enough to keep pace with that delivery.
Researchers at Kumamoto University (Japan)have unveiled a groundbreaking solid electrolyte material that could revolutionize fuel cell technology. Derived from natural clay minerals, this innovative membrane offers high proton conductivity and exceptional hydrogen gas barrier properties—unlocking new possibilities for low- to mid-temperature fuel cells.
A multinational research team has discovered a mysterious tubular structure — previously unknown in any organism — within Profftella, a symbiotic bacterium associated with a major global citrus pest. This discovery, made using advanced microscopy, may lead to breakthroughs in both pest control and the study of life’s evolution.
Dr. Shiki Machida from the Chiba Institute of Technology revealed that the scale of material heterogeneity in the upper mantle caused by mantle plumes is less than 10 km—much smaller than previously thought. This suggests that materials inside the Earth mix and recycle faster than expected, offering new insights into the Earth’s internal structure.
https://www.sciencedirect.com/science/article/pii/S0024493725002348
Origami device fabrication has huge potential in the fields of health, agriculture, and space technology. However, portability of the presently used fabrication devices is a concern and on-site production of three-dimensional (3D) devices remains a challenge. To address this, researchers have developed a portable, multimaterial printer using electrowetting on dielectric technology. This device allows rapid fabrication of 3D devices, eliminating the challenges of the existing technologies and improving the applicability of paper-based devices.
Water is one of the most familiar substances on Earth, yet its behavior under extreme confinement remains poorly understood. In a recent study, researchers from Japan revealed how water confined within nanopores can transition into a unique ‘premelting’ state, behaving partly like ice and partly like liquid water. Using static solid-state deuterium nuclear magnetic resonance spectroscopy, the researchers identified hierarchical molecular structure and uncovered dynamic properties with potential applications in energy storage and materials science.
AIMR researchers developed a unified analytical model that explains how complex orbits—halo, and quasi-halo—emerge near Lagrange points in the restricted three-body problem. By introducing a nonlinear coupling mechanism, their approach reveals that orbit bifurcations arise without requiring frequency resonance, advancing both space trajectory design and bifurcation theory.