In the development of Parkinson’s disease, it may not be a good idea to turn the amp to 11. High-volume noise exposure produced motor deficits in a mouse model of early-stage Parkinson’s disease, and established a link between the auditory processing and movement areas of the brain, according to a study published November 4^th in the open-access journal PLOS Biology by Pei Zhang from the Huazhong University of Science and Technology in Wuhan, China, and colleagues.

BUFFALO, NY — November 3, 2025 — A new research paper featured on the cover of Volume 17, Issue 10 of Aging-US was published on October 20, 2025, titled “Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model.”

Scientists from Duke-NUS Medical School and their collaborators have created one of the most comprehensive single cell maps of the developing human brain. The atlas captures nearly every cell type, their genetic fingerprints, and how they grow and interact. It also benchmarks best-in-class laboratory methods for producing high-quality neurons, marking a major step towards new therapies for Parkinson’s disease and other brain disorders.

An Arkansas woman is the first in the U.S. to undergo a life-changing type of incisionless brain surgery for the treatment of Parkinson’s disease outside of a clinical trial.

Using sequencing and bioinformatic analysis, scientists identified 22 genes with altered expression in drug-naïve Parkinson’s patients, many of which are linked to immune and iron-related pathways. Published in Neurotherapeutics, this exploratory study from UMH, CSIC, and ISABIAL paves the way for blood-based diagnostic tools to detect Parkinson’s disease at earlier stages.