Peer-Reviewed Publication

New study reveals potential link between GLP1 agonists and depression: Calls for urgent attention

Bentham Science Publishers
Peer-Reviewed Publication

A groundbreaking study published in the journal Current Neuropharmacology highlights a concerning potential link between Glucagon-like Peptide-1 (GLP1) receptor agonists—widely used in blockbuster drugs like Ozempic—and the risk of depression and suicidal ideation (SI). Using advanced pharmacogenomic computational analyses, the international team of 24 researchers revealed genetic pathways that may induce depressive phenotypes in users of GLP1 agonists, raising significant concerns about the safety of these medications for certain individuals.

Journal: Current Neuropharmacology

A cool fix for hot chips: Advanced thermal management technology for electronic devices

Institute of Industrial Science, The University of Tokyo
Peer-Reviewed Publication

Researchers from the Institute of Industrial Science, The University of Tokyo, have demonstrated a significant performance increase in cooling technology for high-power electronic devices. They designed novel capillary geometries that push the boundaries of thermal transfer efficiency. This study could play a crucial role in the development of next-generation technology.

Journal: Cell Reports Physical Science

Study identifies new method for improving lung growth and function in preterm infants

Oregon Health & Science University
Peer-Reviewed Publication

A clinical trial conducted at Oregon Health & Science University’s neonatal intensive care unit has identified a new treatment protocol to improve lung growth and function among preterm infants.

Journal: American Journal of Respiratory and Critical Care Medicine

Machine learning model to predict the fitness of AAV capsids for gene therapy

Mary Ann Liebert, Inc./Genetic Engineering News
Peer-Reviewed Publication

A new study in the peer-reviewed journal Human Gene Therapy describes a machine learning (ML) model that can be used as a surrogate for laborious in vitro experiments. This in silico approach aims to increase the fitness of clinical adeno-associated virus (AAV) capsids to make gene therapies more economically viable for patients.

Journal: Human Gene Therapy

MD Anderson Research Highlights for April 17, 2025

University of Texas M. D. Anderson Cancer Center
Peer-Reviewed Publication

The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back.

Research spotlight: Basal cell carcinoma’s low immunogenicity is associated with suppression of antigen presentation stemming from its cell of origin

Mass General Brigham
Peer-Reviewed Publication

Shawn Demehri, MD, PhD, a physician-investigator in the Cutaneous Biology Research Center and Krantz Family Center for Cancer Research at Massachusetts General Hospital and an Associate Professor of Dermatology at Harvard Medical School in the senior author of a new study in Cell Reports, Epigenomic Regulation of Stemness Contributes to the Low Immunogenicity of the Most Mutated Human Cancer.

Journal: Cell Reports
Funder: Burroughs Wellcome Fund, Society for Pediatric Dermatology Weston Career Development Award, LEO Foundation Award

Using AI to predict athletes' risk of lower-extremity injury after concussion

University of Delaware
Peer-Reviewed Publication

A team of researchers have developed an AI model predicting post-concussion injury risk in athletes with 95% accuracy, analyzing more than 100 variables. The machine identifies subtle deficits and has potential beyond sports.

Journal: Sports Medicine

Nutrients strengthen link between precipitation and plant growth, study finds

German Centre for Integrative Biodiversity Research (iDiv) Halle-Jena-Leipzig
Peer-Reviewed Publication

A new study published in PNAS investigated how the relationship between mean annual precipitation (MAP) and grassland biomass changes when one or more nutrients are added. The authors show that precipitation and nutrient availability are the key drivers of plant biomass, while the effects of plant diversity are minimal.

Journal: Proceedings of the National Academy of Sciences
Funder: Deutsche Forschungsgemeinschaft

How should we prioritize patients waiting for kidney transplants?

Massachusetts Institute of Technology
Peer-Reviewed Publication

How should we prioritize patients waiting for kidney transplants? A new study could help policymakers analyze methods of matching donated kidneys and their recipients.

Journal: Econometrica
Funder: U.S. National Science Foundation, Alfred P. Sloan Foundation

The eukaryotic cell emerged as an evolutionary algorithmic phase transition

Johannes Gutenberg Universitaet Mainz
Peer-Reviewed Publication

An international collaboration between four senior scientists from Mainz, Valencia, Madrid, and Zurich has published groundbreaking research in the journal PNAS, shedding light on the most significant increase in complexity in the history of life's evolution on Earth: the origin of the eukaryotic cell.

Journal: Proceedings of the National Academy of Sciences

Study: Experimental bird flu vaccine excels in animal models

University at Buffalo
Peer-Reviewed Publication

A vaccine under development at the University at Buffalo has demonstrated complete protection in mice against a deadly variant of the virus that causes bird flu. The work, detailed in a study published April 17 in the journal Cell Biomaterials, focuses on the H5N1 variant known as 2.3.4.4b, which has caused widespread outbreaks in wild birds and poultry and other mammals. The vaccine is step toward more potent, versatile and easy-to-produce vaccines that public health officials believe will be needed to counteract evolving bird flu strains that grow resistant to existing vaccines.

Journal: Cell Biomaterials

Study finds protein partnership protects chromosomes

Weill Cornell Medicine
Peer-Reviewed Publication

A new study from Weill Cornell Medicine provides insights into how cells maintain the tiny end caps of chromosomes as they divide, a key process in keeping cells healthy.

Journal: Nucleic Acids Research

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