17-Apr-2025
Scientists hack cell entry to supercharge cancer drugs
Duke UniversityPeer-Reviewed Publication
Scientists at Duke University School of Medicine, University of Texas Health Science Center at San Antonio could reshape cancer treatment by helping powerful drugs work better in the body. By exploiting a surface protein called CD36 that helps pull substances into cells. dramatically improves the uptake of a promising class of cancer-fighting drugs called PROTACs, New drug design deliveries up to 22 times more of he drug inside cancer cells, and tumor suppression in mice, according to a study in Cell.
- Journal
- Cell
- Funder
- NIH/National Institutes of Health, University of Texas Health San Antonio, Arkansas Research Alliance Endowed Chair Fund, Duke University School of Medicine, Duke Fred and Janet Sanfilippo Distinguished Professor funds, Arkansas Bioscience Institute, Arkansas Breast Cancer Research Program Pilot Award, Cancer Prevention and Research Institute of Texas