A research team led by Professor Guorui Huang from the Department of Endocrine and Metabolic Diseases at Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, has developed an optimized protocol that fundamentally changes how circulating microvesicles (MVs) are isolated and characterized. The study reveals that commonly used methods unintentionally capture platelet fragments rather than true MVs, leading to decades of misinterpretation of their biological functions. The team’s newly defined 3000 g centrifugation threshold eliminates platelet contamination and provides a standardized foundation for future diagnostic and mechanistic studies on extracellular vesicles.

Researchers at Zhejiang University invented a new vertical Micro/Nanofiber drawing system, enabling precise creation of complex cascaded fibers for high-efficiency supercontinuum generation spanning 1463–1741 nm.​

elderly. This study aims to assess the prevalence, mortality, and disability-adjusted life years (DALY) burden of cancer among individuals aged 60–94 worldwide from 1990 to 2021. Data on the prevalence, mortality, and DALY for 35 cancer types in the elderly were derived from the Global Burden of Disease Study (GBD) spanning 1990 to 2021. The analysis was performed at four stratified levels: global, 21 GBD regions, 204 countries, and five sociodemographic index (SDI) categories. Age-standardized rates for prevalence, mortality, and DALYs were computed. In 2021, the global elderly population (60–94 years) reported 691.13 × 10⁵ [627.13 × 10⁵, 773.82 × 10⁵] cancer cases and 71.86 × 10⁵ [65.07 × 10⁵, 77.31 × 10⁵] cancer deaths, with a DALY total of approximately 1394.17 × 10⁵ [1281.20 × 10⁵, 1495.54 × 10⁵]. Trends indicate a gradual increase in cancer cases and mortality over time, with DALY rates escalating with aging. Notably, high-income North America exhibited the highest age-standardized prevalence. High SDI regions faced the most substantial elderly cancer burden. The burden of cancer among the elderly exhibits considerable variability globally, with developed socioeconomic areas experiencing a greater prevalence than those in underdeveloped regions, necessitating urgent attention from health professionals.

Focusing on the methodological challenges in adapting tissue optical clearing technology to large animals, this review systematically examines the key bottlenecks in transitioning from rodents to large animals, summarizes representative applications in neural circuit mapping and sensory organ visualization in large animal, and offers perspectives on future research directions.

A recent study published in Life Metabolism by Wu et al. from Dalian Medical University addresses this knowledge gap. The researchers developed a liver-specific Ghr knockout (LGHRKO) mouse model that faithfully recapitulates key features of human lean MAFLD. Their findings reveal that CD36-mediated lipid uptake and C/EBPβ-driven lipogenesis form a central regulatory hub driving the disease, providing new mechanistic insight and potential therapeutic targets for lean MAFLD.

The review dissects the computational workflows, strengths, limitations, and future directions of both technologies. It emphasizes that bulk RNA-seq remains the most cost-effective and robust method for analyzing gene expression across large sample sizes—ideal for clinical cohorts, agricultural populations, and time-series studies. In contrast, scRNA-seq offers unprecedented resolution, enabling scientists to uncover cellular heterogeneity, identify rare cell types, and trace developmental trajectories at the single-cell level.

A team of researchers from Tianjin University has developed a novel tree-like nitrogen-doped carbon (T-NC) support structure that addresses key challenges in fuel cell technology—cost, performance, and durability. Published in Front. Energy, this innovation enables low-platinum (Pt) loaded fuel cells to deliver superior efficiency and longer lifespan, bringing the widespread commercialization of hydrogen-powered vehicles one step closer.

Researchers at Beijing University of Technology have developed a new type of acid-stable bimetallic phosphide-silver core-shell nanowire catalyst that significantly improves the efficiency of the hydrogen evolution reaction (HER)，which was published in Frontiers in Energy

 This research investigates the role of TRIM66 and HP1γ in chromatin remodeling, specifically focusing on facultative heterochromatin (fHC) formation. The study reveals that TRIM66 interacts with HP1γ through its PxVxL motif, promoting liquid-liquid phase separation (LLPS) and driving fHC domain formation. This mechanism is crucial for maintaining genomic stability and regulating gene expression.