Okayama University of Science (OUS) in Japan and Minghsin University of Science and Technology (MUST) in Taiwan have signed a Memorandum of Agreement (MOA) to establish a double degree program in semiconductor studies. The agreement, building on a 40-year partnership between the two institutions, will allow students to earn bachelor’s degrees from both universities. Under the program, students begin at OUS to learn semiconductor fundamentals and language skills before advancing to MUST, home of the world’s first Semiconductors School. The initiative aims to cultivate globally minded engineers and strengthen industry–academia collaboration in Okayama and Taiwan. At the signing ceremony held on October 23 at OUS, leaders from both universities and semiconductor companies expressed strong support for developing a joint talent base that will contribute to regional and global semiconductor innovation.

Glycans are important complex carbohydrates found on cell surfaces that serve crucial roles in cell-to-cell communication, structure, and protection. They are attached to many proteins in the body, and their attachment differs protein to protein. Researchers aimed to investigate the selectivity of a specific, cancer-related enzyme, N-acetylglucosaminyltransferase-V (GnT-V or MGAT5). GnT-V is often abnormally upregulated and can be an indicator of a poor prognosis in cancer diagnoses, with N-glycans individually associated with diseases such as Alzheimer's, emphysema, diabetes and cancer. Understanding why and how GnT-V selects substrates may offer therapeutic solutions for diseases involving this enzyme.

Sir2, an enzyme belonging to sirtuins, has been effectively involved in the deacetylation of proteins. A tandem allosteric effect of reactant and product is responsible for the efficient deacetylation cycle of the Sir2 enzyme, reveal researchers from Science Tokyo. This finding reveals a new target for modulating Sir2, an enzyme that is essential for many biological processes, including aging, metabolic regulation, and cancer suppression. This finding could potentially lead to new therapeutic applications, including novel cancer treatments.

An international team led by Japan’s National Institute of Polar Research discovered that large-scale East Antarctic ice loss around 9,000 years ago was amplified by a “cascading positive feedback” between meltwater and ocean circulation. Sediment records and ocean–climate modeling show that meltwater from other Antarctic regions strengthened warm deep-water inflow, accelerating ice-shelf collapse and inland thinning. The finding highlights how Antarctic ice melt can self-reinforce under ongoing global warming.

Researchers may have unlocked a more sustainable and affordable way for producing key ingredients for everyday materials such as plastics, clothing fibers, and insulation foams. The secret: lead dioxide. 

Scientists at the Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a gene-regulating protein forms tiny liquid-like droplets inside the cell nucleus (the compartment that stores and manages DNA) to guard against cancer. Their study, published in Nature Communications, shows that these protein droplets act as control centers that keep tumor-suppressor genes switched on.

Short ultraviolet/ozone (UVO) treatment optimizes cell adhesion on plastic culture substrates by selectively enriching adhesion proteins, as reported by researchers from Institute of Science Tokyo. Their latest study explains the underlying reason why there is an optimal UVO treatment time, with the optimal surface condition arising when the ability to selectively adsorb and immobilize key adhesion proteins is maximized. This study paves the way for the design of polymeric materials used in medical research.

Researchers from the University of Tokyo and Juntendo University have identified a previously unknown structural domain in the motor protein kinesin-2 that enables precise cargo recognition in neurons. This study reveals the “HAC” domain (Hook-like Adaptor and Cargo-binding region) using high-resolution cryo-electron microscopy. This breakthrough sheds light on how motor proteins sort and deliver cargo, with implications for understanding neurodegenerative diseases and cellular transport disorders.

We elucidated that DNA methyltransferase 1 (Dnmt1), an epigenetic regulator, properly controls bone elongation by modulating energy metabolism in growth plate chondrocytes. Epigenetic regulation is influenced by lifestyle factors and affects development and disease. Our study reveals that Dnmt1 determines long bone length through energy metabolic regulation, suggesting that nutritional cues may shape chondrocyte function and providing insights for preventing or treating growth disorders and osteoarthritis.