Missing nitrogen: a dramatic game of cosmic hide-and-seek deep within our planet
Peer-Reviewed Publication
Updates every hour. Last Updated: 12-Jul-2025 19:10 ET (12-Jul-2025 23:10 GMT/UTC)
Neurons migrate through complex brain tissue using distinct strategies, but how they choose remains unclear. A recent study from Japan found that neurons switch migration modes based on their environment. Researchers identified PIEZO1, a mechanosensitive protein, as crucial to this process, helping neurons adapt in confined spaces. These findings enhance our understanding of brain development and may inform therapies for brain injuries and cancer metastasis, offering new insights into neuronal movement and mechanobiology.
Numerous widely used chemicals induce genetic and epigenetic alterations implicated in various diseases, including cancer. Safety assessment of potential carcinogens is necessary to minimize their hazardous impact. While genotoxicity assays are widely used to evaluate genetic changes, quantification of epigenetic changes requires advanced and expensive sequencing techniques. Researchers from Japan have developed a simple and cost-effective cell-based reporter assay that can quantify chemical-induced epigenetic effects, and enhance the safety evaluation of environmental chemicals.
An Osaka Metropolitan University-led study demonstrated that Cdc42 (cell division cycle 42) plays a crucial role in the formation and maintenance of the morphological characteristics of quiescent hepatic stellate cells.