Uncovered a mystery of “electron carrier” existing in all living organisms: Discovery of a “nano-switch mechanism” controlled by a single hydrogen atom
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Updates every hour. Last Updated: 29-Apr-2025 05:08 ET (29-Apr-2025 09:08 GMT/UTC)
A research group of The University of Tokyo has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. This study revealed that the balance between sleep and wakefulness is regulated by the action of multiple enzymes, which is an important finding when considering how to control sleep duration and sleepiness at the molecular level.
Understanding material transformations at the microscopic level is crucial for advancing technology. Researchers from Japan have recently studied liquid crystal phase transitions, revealing the complex dynamics behind their shape-shifting behavior. Using a combination of computer simulations and machine learning, they uncovered how liquid crystals form twin boundaries during phase shifts. The strategy developed in this study could help gain deeper insight into the transformation dynamics in a wide range of materials.
Salicylic acid is vital for protecting plants from pathogens, but its synthesis remains unclear. A recent study by Shinshu University researchers has discovered that the protein HSR201 is key to its production. They found that HSR201 localizes to specific organelles called peroxisomes through a unique targeting signal. This discovery improves our understanding of how plants produce salicylic acid and could pave the way for developing engineered crops with improved disease resistance.
Researchers at Osaka University have identified ARMC5 as a key regulator of fatty acid balance in adipose tissue. ARMC5 degrades non-SCAP-bound SREBP1, activating it to regulate stearoyl-CoA desaturase (SCD), an enzyme essential for fatty acid desaturation. This discovery opens avenues for developing drugs targeting ARMC5 to manage fatty acid levels and improve health outcomes.
A Japanese research team led by Professor Hidetoshi Katori at The University of Tokyo, has achieved a groundbreaking milestone by developing the compact, robust, ultrahigh-precision optical lattice clock with a device capacity of 250 L. The optical lattice clock is expected to serve as a foundational infrastructure for future societal needs, contributing to a wide range of research fields and practical applications.