17-Feb-2025
Breakthrough observation of real-time protein translocation by SecYEG-SecA complex
Nara Institute of Science and TechnologyPeer-Reviewed Publication
Protein translocation across cellular membranes is crucial for moving proteins to specific locations and their extracellular secretion. Recently, researchers from Japan have used high-speed atomic force microscopy to observe SecYEG-SecA complex-mediated bacterial protein translocation in real-time for the very first time. Their study revealed how energy-driven conformational changes in SecA regulate protein movement across the membrane, offering new insights into mechanisms underlying protein transportation and showcasing the potential for several applications in pharmacy and medical science.
- Journal
- Nature Communications
- Funder
- Japan Society for the Promotion of Science, Japan Science and Technology Agency, Natural Science Foundation of Shanghai, Chemo-Sero-Therapeutic Research Institute, Naito Foundation, Takeda Science Foundation, The Institute for Fermentation (Osaka), Yamada Science Foundation, Ministry of Education, Culture, Sports, Science and Technology