Kyoto, Japan -- Asteroids that orbit close to the Earth inevitably cause us some anxiety due to the even remote possibility of a collision. But their proximity also offers ample opportunities to learn more about the universe. Ryugu, a 900-meter diameter asteroid in the Apollo belt, has recently proven useful in our search for signs of life's precursors elsewhere in our Solar System.

A team of researchers at Kyoto University have found evidence of salt minerals in samples recovered from Ryugu during the initial phase of Japan's Hayabusa2 mission. The discovery of these deposits, containing sodium carbonate, halite, and sodium sulfates, suggest that liquid saline water once existed within a parent body of Ryugu.

Before examining the samples, the team expected that sample grains returned from the asteroid might contain substances not generally found in meteorites. They anticipated that these could be highly water-soluble materials, which readily react with moisture in Earth's atmosphere and are difficult to detect unless examined in their pristine state as preserved in the vacuum of space.

Porous organic crystals with superior properties as CO₂ adsorbents were created by researchers at Institute of Science Tokyo. Owing to the novel 2.5-dimensional skeleton, the materials feature ultrahigh-density amines. The covalently-bonded microporous skeleton and high crystallinity realize fast CO₂ adsorption and high thermal stability. Their low adsorption heat, only one-fourth of the current amine scrubbing method, and their light-elemental nature can reduce the cost for CO₂ separation from flue gases.

A recent study led by Associate Professor Takuya Yamamoto and Researcher May Nakajima-Koyama has revealed that maintaining a delicate balance between interferon-gamma (IFN-γ) and extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) signaling is essential for preserving the intestinal stem cell population during aging. By comparing young and aged mouse intestinal tissues, the researchers uncovered critical insights into the interplay between these signaling pathways in supporting stem cell maintenance over time.

Biological motors, which aid microorganism movement in fluids, are composed of two components—the rotor and stators. Despite much research, the exact molecular mechanism underlying stator function is yet unclear. In a new study, researchers from Nagoya Institute of Technology analyzed the flagellar motor in Vibrio alginolyticus using cryo-electron microscopy and described how sodium ion flow through stators underlies stator function. Understanding biological motors better could lead to the development of efficient microscopic machines.

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal cell model, researchers identified and characterized thousands of enhancers active during neuronal differentiation, linked them to target genes, and validated key interactions. This study demonstrates a significant enrichment of GWAS variants associated with Parkinson’s disease and schizophrenia within these enhancers, providing a valuable resource for understanding neuronal development.

A multi-institutional research team led by Osaka University found that tricaprin, a natural supplement, improved long-term survival rates in patients with triglyceride deposit cardiomyovasculopathy, a new type of heart disease characterized by impaired triglyceride breakdown in heart and smooth muscle cells. Tricaprin improved clinical symptoms and long-term survival. Studying the effects of tricaprin on patients of different ethnicities would be an ideal next step to gather more evidence in favor of the drug.

DNA hydrogels are biocompatible drug delivery systems for targeted therapeutic interventions. Conventional DNA hydrogels, formed with many DNA nanostructure units, lead to increased preparation costs and design complexities. To address this, researchers from Japan constructed a Takumi-shaped DNA nanostructure with minimal DNA units and optimized its structure for improved in vivo retention abilities and sustained drug release. This study presents a promising DNA-based drug delivery system, which can potentially improve patient outcomes.