Corn, or maize, is a major crop in the United States, and its derivatives are utilized in practically every facet of our lives. Demand for it grows, even as unpredictable environmental conditions make it difficult for farmers to maintain their current yield. In work recently published in the journal In Vitro Cellular & Developmental Biology – Plant, labs from the Boyce Thompson Institute (BTI) and Iowa State University (ISU) partnered with scientists from Corteva Agriscience to establish a more accessible method for maize bioengineering that will pave the way for improving this critical crop.

BUFFALO, NY — May 1, 2025 — A new research paper was published in Aging (Aging-US) on April 2, 2025, as the cover of Volume 17, Issue 4, titled “Decreased mitochondrial NAD+ in WRN deficient cells links to dysfunctional proliferation.”

University of Tennessee Professor Paul Armsworth, Department of Ecology and Evolutionary Biology, among its cohort of 2025 ESA Fellows.

Cells have a mailing system of sorts. They can release tiny molecular balls, called extracellular vesicles (EVs), that contain biological matter or messages and attach to other cells to share whatever they contain. In cancer, EVs often depart from tumor cells to seed the cancer elsewhere in the body, leading to metastasis. However, how the EVs connected to recipient cells to deliver their payload has remained a mystery — until now. A team of researchers based in Japan has revealed the molecular mechanisms underpinning the process for small EVs (sEVs), which they said could have implications for developing better cancer treatments.

Ferroptosis, a form of programmed cell death mediated by iron, has been a focus for its potential in cancer therapies. Now, researchers have discovered that lysosomal lipid peroxidation plays a critical role in the execution of ferroptosis. They also showed that this leads to iron leakage from the lysosome, further promoting ferroptosis. Additionally, administration of chloroquine—a drug that promotes lysosomal membrane damage—facilitates ferroptosis in cancer cells that are less sensitive to the process.