Researchers at the Institute of Molecular and Clinical Ophthalmology Basel (IOB) report new insights into how cone photoreceptors, the cells responsible for central vision, can be protected from degeneration. Screening more than 2,700 compounds in 20,000 lab grown human retinal organoids, the team found both harmful and protective effects, with inhibition of casein kinase 1 emerging as a key protective mechanism. The study also provides an openly accessible dataset to support the development of new therapies for vision loss.