Epigenetic changes regulate gene expression, but what regulates epigenetics?
Peer-Reviewed Publication
Updates every hour. Last Updated: 22-Nov-2025 10:11 ET (22-Nov-2025 15:11 GMT/UTC)
All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes get expressed in each cell. If epigenetic changes regulate our genetics, what is regulating them? Salk scientists have now used plant cells to discover that a type of epigenetic tag, called DNA methylation, can be regulated by genetic mechanisms. Prior to this study, scientists had only understood how DNA methylation was regulated by other epigenetic features, so the discovery that genetic features can also guide DNA methylation patterns is a major paradigm shift. Their findings could inform future epigenetic engineering strategies aimed at generating methylation patterns predicted to repair or enhance cell function, with many potential applications in medicine and agriculture.
Whether you’re a home gardener or an industrial farmer, you might be familiar with mulching films — plastic sheets laid over the soil to protect seedlings and promote crop growth. But like many other plastic materials, these films can release damaging microplastics and don’t have any insect-repelling power. So, a team reporting in ACS Agricultural Science & Technology has developed an alternative biodegradable mulching film that also naturally repels pests using citronella oil.
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