About The Study: In this randomized clinical trial, psilocybin appeared to be safe and efficacious for treating cocaine use disorder among individuals from underrepresented and vulnerable populations. Further research is warranted to replicate and expand these findings.

MetaEase is a method that allows engineers to quickly and easily stress-test a networking algorithm before deployment, catching failure modes that might otherwise only appear in a real outage.

About The Study: The findings of this systematic review and meta-analysis suggest that single and repeated intravenous ketamine infusions are efficacious in reducing suicidal and depressive symptoms in patients with a major depressive episode in the acute phase, while longer-term outcomes are not well established. 

About The Study: This systematic review and meta-analysis indicates that differences exist between adjunctive atypical antipsychotics in the treatment of major depressive disorder with respect to overall efficacy and acceptability, which should be simultaneously considered. The absence of adequate and well-controlled studies documenting maintenance efficacy of adjunctive atypical antipsychotics in major depressive disorder remains a knowledge gap. 

About The Study: In this randomized clinical trial, genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) did not improve control of depression symptoms at 3 months compared with usual care but was associated with higher depression remission rates at 6 months. These findings suggest a possible longer-term clinical benefit and indicate that future studies should focus on the durability and long-term impact of genotype-guided prescribing in the management of depressive symptoms.