In August 2017, the National Natural Science Foundation of China (NSFC) launched the Major Research Plan “Dynamic Modifications and Chemical Interventions of Biomacromolecules” (implementation period 2017–2025). Through interdisciplinary research that integrates chemistry, life sciences, medicine, mathematics, materials science, and information science, its aim is to develop specific labeling methods and detection techniques for dynamic chemical modifications of biomacromolecules, elucidate the recognition mechanisms and biological functions of dynamic modifications in the regulation of cellular traits, and discover potential drug targets and corresponding lead compounds related to dynamic biomacromolecular modifications. Since its establishment, this Major Research Plan has achieved significant progress and original results in many aspects such as the dynamic properties of biomacromolecular chemical modifications, regulatory mechanisms, and chemical interventions. Recently, members of the expert group, management group, and secretariat of the program collaborated to systematically review representative research achievements obtained since the program’s implementation, and jointly published a review article in CCS Chemistry. This review provides important references for promoting development in related frontier fields, as well as for the future trend of integration between chemistry, life sciences, and medicine.

Researchers at the University of Maine are theorizing that human beings may be in the midst of a major evolutionary shift — driven not by genes, but by culture. Cultural practices — from farming methods to legal codes — spread and adapt far faster than genes can, allowing human groups to adapt to new environments and solve novel problems in ways biology alone could never match. According to the research team, this long-term evolutionary transition extends deep into the past, it is accelerating and may define our species for millenia to come.