One person’s side effect could be another person’s treatment if we expand our perspective on small molecule drug targets, according to a new study published November 5, 2025, in npj Precision Oncology.

“Small molecules can have different targets and effects depending on the disease and cell type, and we can use this knowledge to repurpose more drugs to treat more patients,” said lead author Sanju Sinha, PhD, an assistant professor at Sanford Burnham Prebys.

Researchers from Stockholm University have – for the first time ever – managed to successfully isolate and sequence RNA molecules from Ice Age woolly mammoths. These RNA sequences are the oldest ever recovered and come from mammoth tissue preserved in the Siberian permafrost for nearly 40,000 years. The study, published in the journal Cell, shows that not only DNA and proteins, but also RNA, can be preserved for very long periods of time, and provide new insights into the biology of species that have long since become extinct.

Los Angeles, CA – November 14, 2025 -   The Terasaki Institute for Biomedical Innovation (TIBI) is pleased to announce its collaboration with the California Institute of Technology (Caltech) on a newly awarded $2.8 million Discovery Stage Research (DISC0) grant from the California Institute for Regenerative Medicine (CIRM).

Researchers have announced the rediscovery of Moema claudiae, a species of seasonal killifish in Bolivia that was previously thought to be possibly extinct. This rediscovery provides new hope for the conservation of this unique fish and the diverse wetland habitats of the region.

Understanding how the brain learns and applies rules is the key to unraveling the neural basis of flexible behavior. A new study from the University of Toyama, Japan, reveals that our ability to follow procedural rules is encoded in the evolving dynamics of neuronal activity in the medial prefrontal cortex (mPFC).

Patient-derived xenograft (PDX) models are emerging as a transformative tool in colorectal cancer (CRC) research, offering unparalleled insights into tumor biology, drug resistance, and personalized treatment approaches. These models, created by transplanting fresh human tumor tissue into immunodeficient mice, faithfully replicate the genetic, histological, and molecular features of the original tumors. As such, they serve as invaluable resources in the study of tumor heterogeneity and in the development of precision oncology.