Restoring both walking and sensation to patients with paraplegia is an ambitious goal—but a team of researchers from the Keck School of Medicine of USC, the University of California, Irvine (UCI) and the California Institute of Technology (Caltech) is now one step closer. With $8 million in funding from the highly competitive National Science Foundation CyberPhysical Systems program, the team is building a fully implantable brain-computer interface (BCI) that allows patients to use their thoughts to control wearable robotic legs, known as a robotic exoskeleton. The system is designed to help patients walk while also restoring the sensation of walking. In the first full test, the BCI was about 92% accurate at both reading step signals from the brain and delivering artificial walking sensation. Existing brain-computer interfaces that restore walking send signals in just one direction, from brain to device. The team’s early proof-of-concept study, done in a patient with epilepsy who had electrodes implanted as part of her medical care, shows it is possible to build a bidirectional, or two-way, system. During the demonstration, the patient sat on her hospital bed with the device by her side (future versions will be small enough to implant inside the body), while one of the researchers wore the robot exoskeleton. When the patient mimed taking a step, the device signaled the exoskeleton, sending the researcher on a walk around the intensive care unit. The system correctly detected brain signals indicating the intent to walk about 92% of the time. The demonstration helped the researchers earn an Investigational Device Exemption from the U.S. Food and Drug Administration, which allows them to test the device in a clinical trial for patients with paraplegia. They aim to implant electrodes for 30 days as a time, using that window to test and refine the system’s capabilities.

Sustainable aviation fuel (SAF) will play a critical role in decarbonizing the aviation industry. Among SAF production pathways, alcohol-to-jet stands out for its scalability, supported by abundant feedstock availability and a well-established bioethanol industry. However, significant reductions in SAF carbon intensity require the use of cellulosic feedstocks, whose adoption is hindered by high capital costs for feedstock processing and ethanol upgrading. A study by researchers at the Center for Advanced Bioenergy and Bioproducts Innovation (CABBI) demonstrated that leveraging established petroleum infrastructure can facilitate SAF deployment via cellulosic alcohol-to-jet coprocessing to enable cost-effective, low-carbon aviation fuels.