About The Study: From this large, multisite registry, results reveal that women with pregnancy-associated spontaneous coronary artery dissection (P-SCAD) had greater median ages at gestation, greater history of assisted reproductive technology use, and greater instances of multigravida and preeclampsia than women with non–pregnancy-associated SCAD (NP-SCAD) and the general reproductive-aged U.S. population. With high percentages of vascular imaging among participants, women with P-SCAD had less fibromuscular dysplasia but similar rates of extracoronary abnormalities including dissection and aneurysms as women with NP-SCAD. In this contemporary cohort, women with P-SCAD continue to represent a higher-risk phenotype with predominantly conservative management; however, they had less left ventricular ejection fraction recovery.