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Updates every hour. Last Updated: 12-May-2026 02:16 ET (12-May-2026 06:16 GMT/UTC)
Scientists use heterocycles to target cancer toward safer, smarter treatments
FAR Publishing LimitedThe way a drug works and what it targets in the body are key factors in how effectively it can kill harmful cells. This work looks at a group of important proteins called receptor tyrosine kinases, which are often involved in diseases like cancer. Scientists have found that certain chemical structures—called heterocycles, such as pyrimidine, thiazole, imidazole, indole, acridone, and triazine—can be used to make drugs that target these proteins. With some changes, these compounds could also be designed to affect other disease pathways in the future.
The endocytic pathway for absorption of exogenous RNAs in Verticillium dahliae
SciOpenRNAi technologies have been exploited to control viruses, pests, oomycetes and fungal phytopathogens that cause disasters in host plants, including many agronomically significant crops. However, it is unclear what process mediates RNA uptake by fungi. Here, the authors utilized live-cell imaging technology combined with molecular biology experiments to demonstrate that exogenous RNA is indiscriminately absorbed by Verticillium dahliae, the notorious plant pathogenic fungus. The uptake of exogenous RNA by fungal cells is predominantly mediated through endocytosis. This study not only provides a new theoretical foundation for applying trans-kingdom RNA interference technology in crop protection but also lays the groundwork for research and applications of exogenous RNA in plant-fungi interaction systems.
- Journal
- mLife
Isolation and proteomic study of fish liver lipid droplets
Higher Education PressThis study focuses on lipid droplets (LDs), which are organelles responsible for storing neutral lipids and are found across various species. The excessive accumulation of these lipids in LDs is linked to several metabolic disorders. Zebrafish, with their transparent embryos, present a valuable model for studying LD biology, though previous research has been hampered by the absence of specific LD marker proteins and limitations in purification techniques.
- Journal
- Biophysics Reports
- Funder
- National Key Research and Development Program of China, National Natural Science Foundation of China
Supercomputer simulations show how to speed up chemical reaction rates
DOE/Oak Ridge National Laboratory- Journal
- JACS
LPS-treated stem cells show reduced healing in stroke therapy choose
FAR Publishing LimitedA new study shows that treating mesenchymal stem cells with lipopolysaccharide (LPS) shifts their energy use toward glycolysis, reducing their healing potential in stroke therapy — offering insights into improving cell-based treatments for brain injuries.
- Journal
- BIOCELL
- Funder
- Russian Science Foundation
Molecular structure determined for efflux pumps that confer tuberculosis bedaquiline resistance
University of Alabama at BirminghamThe protein MmpL5 is an efflux transporter, a critical pump that helps the pathogen M. tuberculosis grow by scavenging essential iron. Unfortunately, overexpressed MmpL5 can also pump out bedaquiline — the first new turberculosis drug in over 40 years — making the bacteria drug-resistant. Diabling the efflux transporter of M. tuberculosis with an inhibitor would strike a double blow — restore microbial sensitivity to antibiotic bedaquiline and break the cycle that gathers scarce iron. Researchers have now solved the structure of MmpL4, a close homolog of MmpL5 that has the same function.
- Journal
- Nature Communications
Excitation–inhibition balance controls synchronization in a simple model of coupled phase oscillators
Osaka Metropolitan UniversityOsaka Metropolitan University researchers provide valuable insights into the role of excitation–inhibition balance in synchronizing coupled oscillators and neurons.
- Journal
- Neural Computation
How black wolfberry makes its antioxidant armor?
Nanjing Agricultural University The Academy of ScienceFamed for its deep purple berries and potent antioxidant properties, black wolfberry (Lycium ruthenicum) thrives in harsh desert climates and holds significant nutritional and medicinal value.
- Journal
- Horticulture Research