New method searches through 10 sextillion drug molecules
Peer-Reviewed Publication
Updates every hour. Last Updated: 8-Jul-2025 06:10 ET (8-Jul-2025 10:10 GMT/UTC)
A new mathematical model developed at the University of Waterloo can determine a baby’s overall drug exposure when their mother is taking medication. This is the first study to include drug transfer from the umbilical cord and through breastfeeding in determining the baby's total drug levels.
The research team from the School of Pharmacy at Waterloo looked specifically at Levetiracetam. It is a drug commonly prescribed long term for women with epilepsy, yet there was minimal data on the risk of adverse effects on breastfed infants.
In a paper published in National Science Review, a team of Chinese scientists developed an attention-based deep learning model, CGMformer, pretrained on a well-controlled and diverse corpus of continuous glucose monitoring (CGM) data to represent individual’s intrinsic metabolic state and enable clinical applications. It can accurately characterize individual dynamic glycemic behaviors such as maintenance of fasting blood glucose homeostasis and adaptation to postprandial hyperglycemia., It can assist in the diagnosis, disease duration assessment, and complication prediction of type 2 diabetes, subtype classification of non-diabetic populations, predict postprandial glucose responses accurately and provide personalized dietary recommendations for diabetes patients, thereby enabling lifestyle intervention recommendations.