Researchers led by a University of Ottawa Faculty of Medicine team offer highly compelling evidence that an elegant, nature-inspired solution lies in ultra-tiny, bubble-like structures called small extracellular vesicles (sEVs). These metabolic messengers refined over millions of years of evolution carry RNA – a nucleic acid that is a chemical cousin of DNA – and other molecules between cells. In a nutshell, the research team’s new findings show that not all sEVs are alike: their cell of origin determines where they travel, with certain vesicles naturally targeting specific tissues in the body.