Inflammation is central to coronary artery disease, yet many anti-inflammatory strategies have failed to improve cardiovascular outcomes. A new Science Bulletin review explains why and proposes a “4R framework”—right target, right patient, right timing and right benefit–risk balance—to guide precision anti-inflammatory therapy.

Agricultural education researchers surveyed 793 school-based agricultural educators in 13 Southern states, Puerto Rico and the U.S. Virgin Islands to learn more about their levels of awareness to farm stressors and suicide warning signs. The results paint a largely encouraging picture, because they showed that school-based agricultural educators generally recognized most suicide warning signs and farm stressors. However, an unexpected finding was that school-based ag teachers described as “urban” were among the groups who were more likely to recognize farm stressors than teachers from “rural” communities.

Forest canopies are more than just a ceiling of leaves—they are living archives of ecosystem health, carbon storage, and biodiversity. 

Electronic skin (e-skin), a stretchable, conformable, and multimodal sensing platform, is rapidly advancing in healthcare, robotics, and human–machine interaction (HMI). However, prolonged wear and sweat accumulation at the e-skin-skin interface can introduce signal artifacts, cause discomfort, and eventually lead to interfacial failure. Inspired by the unidirectional liquid transport of the Nepenthes peristome, we constructed an intelligent breathing e-skin (SPTL) featuring a Janus bilayer structure that creates a “liquid diode” effect for active sweat transport, achieving a remarkable cumulative one-way transport index of 956.36 while maintaining a dry interface even under profuse perspiration. This device exhibits a high tensile strain of 627%, a breathability of 20.02 mm s−1, and a pressure sensitivity of 7.39 kPa−1. Furthermore, the SPTL demonstrates versatile multimodal sensing capabilities, including real-time Morse code and non-contact capacitive sensing, while sustaining stable performance over 10,000 pressing cycles (capacitance decay < 3%). As a bio-integrated electrode, SPTL enables high-fidelity acquisition of electroencephalogram (EEG), electromyogram (EMG) and electrocardiogram (ECG) signals, significantly outperforming commercial Ag/AgCl electrodes. Integrated with machine learning algorithms and EMG signals captured by the SPTL, it facilitates precise teleoperation of a quadruped robot and handwritten letter recognition with over 95% accuracy. This bionic strategy provides a versatile solution for intelligent, breathable, and multimodal bio-integrated interfaces.

With the global aging trend intensifying, cancer presents a significant health challenge for the elderly. This study aims to assess the prevalence, mortality, and disability-adjusted life years (DALY) burden of cancer among individuals aged 60–94 worldwide from 1990 to 2021. Data on the prevalence, mortality, and DALY for 35 cancer types in the elderly were derived from the Global Burden of Disease Study (GBD) spanning 1990 to 2021. The analysis was performed at four stratified levels: global, 21 GBD regions, 204 countries, and five sociodemographic index (SDI) categories. Age-standardized rates for prevalence, mortality, and DALYs were computed. In 2021, the global elderly population (60–94 years) reported 691.13 × 10⁵ [627.13 × 10⁵, 773.82 × 10⁵] cancer cases and 71.86 × 10⁵ [65.07 × 10⁵, 77.31 × 10⁵] cancer deaths, with a DALY total of approximately 1394.17 × 10⁵ [1281.20 × 10⁵, 1495.54 × 10⁵]. Trends indicate a gradual increase in cancer cases and mortality over time, with DALY rates escalating with aging. Notably, high-income North America exhibited the highest age-standardized prevalence. High SDI regions faced the most substantial elderly cancer burden. The burden of cancer among the elderly exhibits considerable variability globally, with developed socioeconomic areas experiencing a greater prevalence than those in underdeveloped regions, necessitating urgent attention from health professionals.

Among adults with hypertension, modifiable risk factors differed substantially in their contributions to cardiovascular disease burden. More favorable cardiovascular health profiles were consistently associated with lower risks across eight cardiovascular outcomes. Nicotine exposure showed the largest population-attributable fractions across several diseases, followed by body mass index, highlighting the potential importance of risk factors beyond blood pressure control. Multi-omics analyses further identified proteins and metabolites that partially accounted for these associations and implicated inflammation-related pathways, including cytokine–cytokine receptor interactions, as potential biological correlates.