Through lipidomic and proteomic analyses, this study reveals how the Mariana Trench snailfish adapts to extreme deep-sea conditions. Findings highlight the fish’s unique lipid regulation, energy storage, and antioxidant mechanisms that enable survival under high pressure and low temperatures.

In China, the real-world effectiveness and safety of Janus kinase 1 (JAK1) inhibitors for moderate-to-severe atopic dermatitis (AD) are of significant interest due to the approval of upadacitinib and abrocitinib in the country. Despite their demonstrated efficacy in clinical trials, there is a scarcity of real-world data, particularly pertaining to Asian demographics. Addressing this gap, a single-center, 24-week prospective study was undertaken at Xiangya Hospital to evaluate the practical application of abrocitinib and upadacitinib in a Chinese cohort of AD patients.