Early withdrawal of a treatment for patients with a rare kidney disease is possible without relapse, safer for patients and saves the NHS millions of pounds, new research has revealed.

*Note this is an early release from the Annual Meeting of the European Association for the Study of Diabetes (EASD 2025, Vienna, 15-19 September). Please credit the meeting if using this material*

New research to be presented at this year’s Annual Meeting of the European Association for the Study of Diabetes (EASD) in Vienna, Austria (15-19 September) shows, among people recently diagnosed with type with type 2 diabetes and no previous cardiovascular disease, a clear association exists between a person’s self-reported physical activity and their risk of all-cause mortality and major adverse cardiac events (MACE), that include heart attacks and strokes. The study is by Ms Line Eriksen and Dr Sidsel Domazet, Steno Diabetes Centre Odense, Odense University Hospital, Odense, Denmark, and colleagues.

For some patients with gastrointestinal (GI) cancers like colorectal and pancreatic cancer chemotherapy can cause severe, sometimes life-threatening side effects in those who carry certain genetic variants that can impact how their bodies process the drugs used to treat their disease. Testing for variants in two genes before starting chemotherapy can significantly improve patient safety by providing physicians with information to help tailor doses, according to new research from the Perelman School of Medicine at the University of Pennsylvania, published today in JCO Precision Oncology, showed that dose adjustments based on preemptive genetic testing cut chemotherapy side effects in half, as compared to similar patients given standard doses without testing.

"In just the last two years, LJI scientists have uncovered a whole new body of information about how the immune systems of men and women are very different."

For patients with amputations affecting the hand, toe transfer surgery provides an alternative to replanting the amputated digits and may lead to greater improvement in hand function and other key outcomes, reports a study in the August issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS). The journal is published in the Lippincott portfolio by Wolters Kluwer.