Chronic liver disease (CLD) affects millions worldwide and lacks a universal cure. While vitamin D is widely recognized for its role in bone health, its impact on liver disease remains underexplored. Researchers in Korea have now shown that vitamin D supplementation can reduce liver inflammation and fibrosis by activating the TXNIP gene in ductular cells. These findings suggest vitamin D could be a promising, low-cost complementary therapy for managing CLD progression.

An international collaborative study has identified the E2F2 protein as a potential new therapeutic target to prevent metabolic fatty liver disease from progressing towards more serious conditions, such as cirrhosis or liver cancer.