Researchers awarded $10.5 million to study use of AI in addressing cardiovascular disease
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Updates every hour. Last Updated: 1-Jan-2026 13:11 ET (1-Jan-2026 18:11 GMT/UTC)
During most eye infections or injuries, neutrophils, immune cells found in the blood, are usually the first line of defense. However, researchers at the Flaum Eye Institute and Del Monte Institute for Neuroscience at the University of Rochester have discovered that the retina responds differently than many other tissues in the body. When photoreceptor cells in the retina are damaged, microglia, or the brain’s immune cells, respond, and the neutrophils are not recruited to help despite passing through nearby blood vessels.
A new article appearing in the current issue of the peer-reviewed Journal of Agriculture and Food Chemistry explores the concept of “superfoods” and makes a case that fresh grapes have earned what should be a prominent position in the superfood family.[1] The author, leading resveratrol and cancer researcher John M. Pezzuto, Ph.D., D.Sc., Dean of the College of Pharmacy and Health Sciences at Western New England University, brings forth an array of evidence to support his perspective on this issue.
[1] Pezzuto, John M. (2025). Perspective: Are Grapes Worthy of the Moniker Superfood? J. Agric. Food Chem. Doi: 10.1021/acs.jafc.5c05738
In fighting chronic infections or certain cancers, CD8+ T cells—the immune system’s frontline soldiers—eventually become exhausted. They lose effectiveness and respond less efficiently to threats. This weakening is a major therapeutic challenge, as it limits the body’s ability to fight chronic infections.
However, the team of Professor Simona Stäger at Institut national de la recherche scientifique (INRS), in collaboration with colleagues from INRS and McGill University, has identified a key game changer: IRF-5. This transcription factor appears to preserve the energy and vitality of CD8+ T cells by acting directly on their metabolism.
These findings, recently published in The EMBO Journal, highlight the importance of fundamental research in understanding the immune system and developing innovative therapeutic approaches.
Salk Institute Professor Diana Hargreaves was named a 2025 All-Star Translational Award Program grantee by the V Foundation for Cancer Research. The award comes as a recognition of Hargreaves’ exceptional success with her previous V Foundation grant in 2016. For the All-Star project, she will receive $1 million and work with collaborator Gregory Botta, an associate professor at UC San Diego Moores Cancer Center, to improve immunotherapy—a treatment that utilizes the body’s own immune cells to fight cancer—in patients with pancreatic cancer.
The commonly held belief that people become happier after 50 appears to apply mainly to unemployed men. At age 50, unemployed men were more than twice as likely to report symptoms of depression as those who had lost a spouse. By age 65, when retirement becomes the norm, the mental health gap between employed and unemployed men disappears entirely. The findings suggest this improvement stems not from biology or lifestyle, but from easing social expectations around work.