A research team led by Dr. Takao Seki (Assistant Professor) and Dr. Hiroyasu Nakano (Specially Appointed Professor) at the Faculty of Medicine, Toho University, has uncovered a previously unknown intercellular network that promotes liver fibrosis. Their findings highlight the critical roles of hepatic stellate cells and two key molecules: the growth factor FGF18 and the pro-fibrotic mediator osteopontin (OPN).

This study evaluated the impact of drinking water, sanitation, and hygiene (WASH) on cholera across 89 low- and middle-income countries. Protective effects against cholera were observed for certain types of improved WASH facilities (e.g., piped water), while harmful effects were noted for unimproved facilities (e.g., open defecation). The disparities in WASH access contributed to inequalities in cholera burden across different regions under the United Nations Sustainable Development Goals (UN SDG) framework.

A Chinese research team has successfully utilized geostationary satellite communication (632 ms latency) to remotely control robotic surgical systems in Beijing from Lhasa, performing precision liver resection surgeries on two liver cancer patients. Intraoperative robotic arm tracking error remained below 0.5 mm, with both patients discharged within 24 hours postoperatively and no severe complications reported. This study marks the first validation of safety in remote surgery under high-latency satellite conditions, offering a groundbreaking solution for underserved regions, disaster zones, and space medicine.  

A new nanoparticle capable of carrying much higher doses of drugs while staying stable for extended periods could make treatments more effective and cause fewer side effects.

Hepatitis B virus-induced hepatocellular carcinoma (HCC) remains a major global health burden, and new therapeutic and diagnostic approaches are urgently needed. Emerging research highlights the crucial role of circular RNAs (circRNAs) in disease progression, offering promising avenues for early detection and innovative treatments. These non-coding RNA molecules, known for their stability and regulatory functions, are proving to be pivotal in tumor biology and immune response modulation.

The role of Fibroblast Growth Factor 8 (FGF8) in embryonic development and organ formation is gaining increased recognition as scientists uncover its wide-ranging influence. FGF8, a powerful signaling molecule, is essential for orchestrating the growth and differentiation of multiple tissues, including craniofacial structures, limbs, internal organs, and the brain. Any disruption in its function can lead to developmental disorders, highlighting its critical importance in normal growth processes.