Microbes reveal missing link in space manufacturing
International Space Station U.S. National LaboratoryResearch sponsored by the International Space Station (ISS) National Laboratory shows that microgravity disrupts how engineered microbes absorb nutrients, limiting their ability to produce useful materials in space. Published in npj Microgravity, the study examined Escherichia coli engineered to produce melanin—a protective pigment that could help shield astronauts and spacecraft from radiation and environmental stress. While the microbes successfully activated the genetic pathway for melanin production, nutrient uptake was impaired in microgravity, leaving key resources unused. Complementary ground-based experiments confirmed that fluid mixing and nutrient transport are major challenges. In contrast, fungal strains tested in the study remained resilient and continued producing melanin, highlighting their potential for space-based biomanufacturing. The findings will inform the design of future bioreactors and systems to enable reliable production of protective materials, medicines, and other valuable compounds during long-duration missions.