A new study published in Life Metabolism reports that a single post-meal blood biomarker, 1-hour postprandial SPARC (SPARC-1H), can predict who will benefit most from adopting a Mediterranean diet. The discovery provides one of the clearest examples to date of how precision nutrition can identify individualized dietary responses using a simple blood test rather than complex multi-omics models.

Glycine, a non-essential amino acid derived from serine, plays an increasingly recognized role in metabolic regulation. Epidemiological studies consistently show that reduced circulating glycine levels are associated with insulin resistance, type 2 diabetes (T2D), and obesity across diverse populations. However, the molecular mechanism linking glycine to insulin production has remained incompletely understood, limiting therapeutic applications.

Metabolic dysfunction-associated steatotic liver disease (MASLD), a spectrum of liver conditions ranging from simple steatosis to steatohepatitis (MASH), fibrosis, and cirrhosis, represents a global health epidemic with no approved pharmacotherapies.

The liver plays a central role in maintaining systemic energy homeostasis during fasting by mobilizing lipid reserves, a process often accompanied by transient hepatic steatosis. Dimethylarginine dimethylaminohydrolase 1 (DDAH1), a key enzyme metabolizing asymmetric dimethylarginine (ADMA), has been shown to protect against NAFLD under nutrient-overload conditions. However, its role in the physiological context of fasting remained elusive.

Emerging evidence reveals that dysregulated autophagy, particularly the selective degradation of lipid droplets (lipophagy), is crucial to maintaining hepatic lipid balance, yet how its activity is regulated under different metabolic conditions has long been an open question.

A review published in UroPrecision synthesizes clinical evidence on high-intensity focused ultrasound for localized prostate cancer and highlights that intraoperative prostate compression is a promising technical refinement that enhances treatment precision and outcomes.

A review published in UroPrecision synthesizes current knowledge on prostatic stromal tumor of uncertain malignant potential (STUMP), a rare prostatic neoplasm with unpredictable clinical behavior. The review, based on 84 patients from 14 studies, highlights the demographic, clinical, and pathological characteristics, diagnostic approaches, and treatment modalities for STUMP.

High glucose uptake by cancer cells is one of the most widely recognized features of tumor metabolism and provides an important biological basis for positron emission tomography/computed tomography (PET/CT) imaging. Although this phenotype is commonly attributed to the energetic and biosynthetic demands of rapid proliferation, glucose-derived carbon is also distributed among multiple downstream pathways.