18-Aug-2026 DDAH1 controls hepatic lipid metabolism under fasting Higher Education Press The liver plays a central role in maintaining systemic energy homeostasis during fasting by mobilizing lipid reserves, a process often accompanied by transient hepatic steatosis. Dimethylarginine dimethylaminohydrolase 1 (DDAH1), a key enzyme metabolizing asymmetric dimethylarginine (ADMA), has been shown to protect against NAFLD under nutrient-overload conditions. However, its role in the physiological context of fasting remained elusive. Journal Life Metabolism
18-Aug-2026 From brain wiring to stress and metabolism: One gene has a finger on the switch Weizmann Institute of Science A new study from the Weizmann Institute of Science reveals a previously unknown biological link between mental and physiological stress responses: They are orchestrated by a single “mastermind” gene, a kind of master switch that is active in the brain even before birth. The study, published recently in Endocrinology, shows that this gene, called Orthopedia, or Otp – long known to play a key role in building the developing brain – remains active into adulthood, helping regulate key hormonal systems that determine how the brain controls stress, metabolism and even behavior. Journal Endocrinology
18-Aug-2026 miR-378 as a metabolic-state-dependent switch controling liver autophagy and fat accumulation Higher Education Press Emerging evidence reveals that dysregulated autophagy, particularly the selective degradation of lipid droplets (lipophagy), is crucial to maintaining hepatic lipid balance, yet how its activity is regulated under different metabolic conditions has long been an open question. Journal Life Metabolism
17-Aug-2026 Quinone-transporting filaments expand bioenergetic capacity in Gram-positive Bacillota Monash University We found that some bacteria build long, hollow filaments that extend their respiratory machinery away from the membrane and into the cell. These filaments are made from proteins and lipids with a hollow interior that electron-carrying molecules can move through, effectively creating power cables within the cell. This allows many energy-processing enzymes to work beyond the cell membrane, expanding respiratory capacity without the bacterium having to build additional membranes or fundamentally reorganise its structure. Journal Nature Microbiology
13-Aug-2026 Minimal impact of genetic disturbance found in endangered butterfly Luehdorfia japonica introduced from distant regions in the past Osaka Metropolitan University An Osaka Metropolitan University-led research team quantified the genetic disturbance in the endangered butterfly Luehdorfia japonica. Journal Entomological Science
12-Aug-2026 Effects of light on fecal case-bearing larvae of the leaf beetle Osaka Metropolitan University Osaka Metropolitan University researchers examined the relationship between herbivory and protection against Chl phototoxicity in leaf beetle larvae. Journal Journal of Chemical Ecology
12-Aug-2026 Special Issue on Andrology and Sexual Medicine Higher Education Press This special issue of UroPrecision (Volume 4, Issue 1) brings together 8 high-quality articles, including 6 Special Issue Articles and 2 Regular Articles, written by internationally recognized experts, focusing on the most discussed “Hot Topics” in sexual medicine and andrology. The issue addresses conditions that remain discussable and not widely defined, rather than comprehensively covering all developments. All manuscripts are written under the guidance of recent literature and aim to update physicians on current, evidence-based information. Below are summaries of each contribution. Journal UroPrecision
10-Aug-2026 Surgery for locally advanced stage IIIB (T4N2) EGFR-mutated lung adenocarcinoma in the era of targeted therapy: a case report Higher Education Press A 60-year-old woman with stage IIIB (T4N2) EGFR-mutated lung adenocarcinoma invading the distal trachea and superior vena cava underwent curative-intent surgery after neoadjuvant chemotherapy. The complex procedure, planned with 3D modeling, included a right upper double-sleeve bilobectomy, tracheal bifurcation sleeve resection, and SVC replacement with a xenopericardial conduit. Adjuvant osimertinib provided 35 months of recurrence-free survival. Subsequent relapse with MET amplification responded transiently to crizotinib; the patient survived 42 months post-surgery, illustrating the potential of multimodal therapy in selected patients. Journal Malignancy Spectrum
10-Aug-2026 A histopathological spectrum, descriptive epidemiology and survival status of ovarian cancer cases from a tertiary cancer center in northern India: a retrospective cohort study Higher Education Press This retrospective cohort study evaluated the demographic profile, treatment patterns, and survival outcomes of 437 ovarian cancer patients treated at a tertiary cancer centre in Bihar, India, between January 2019 and December 2023. Most patients presented at advanced stages (III–IV, 74.6%), with serous carcinoma being the most common histotype (52.5%). Median overall survival was 22.7 months, with 1-year, 2-year, and 5-year OS rates of 68.9%, 46.5%, and 20.6%, respectively. Surgery followed by chemotherapy was associated with significantly better outcomes. Late diagnosis remains a major challenge, underscoring the need for improved screening in rural areas. Journal Malignancy Spectrum
