A research team led by Professor Xiang David Li from the Department of Chemistry at The University of Hong Kong (HKU), in collaboration with researchers from the Shenzhen Bay Laboratory and Tsinghua University, has made a breakthrough in epigenetic drug discovery. The team has successfully developed a first-in-class chemical inhibitor that precisely and selectively targets the ATAC complex, a critical cellular “switch operator” that activates tumour-promoting genes, opening a novel therapeutic avenue for non-small cell lung cancer (NSCLC). The findings were recently published in the top-tier journal Nature Chemical Biology, and multiple international patent applications have been filed.

Seeing chemistry unfold inside living cells is one of the biggest challenges of modern bioimaging. Raman microscopy offers a powerful way to meet this challenge by reading the unique vibrational “signatures” of molecules. However, cells are extraordinarily complex environments filled with thousands of biomolecules. To make specific molecules stand out, researchers often attach small chemical “probes,” such as alkyne tags, that produce signals in a so-called cell-silent spectral window where native cellular components do not scatter light. This allows Raman microscopes to selectively detect the tagged molecules against an otherwise crowded molecular background. Despite this advantage, the widespread adoption of Raman microscopy in biology has been limited by one fundamental problem: Raman signals are extremely weak. In a new study published in Angewandte Chemie International Edition, TIFR researchers report a molecular design strategy that dramatically amplifies Raman signals, enabling the development of Raman sensors that can detect biomolecules using standard spontaneous Raman microscopes. These new Raman sensors enable sensitive, ratiometric imaging of biological molecules and ions, such as hydrogen peroxide molecules, copper ions, and pH, inside living cells. The work is supported by the Department of Atomic Energy, Government of India, and the Japan Science and Technology Agency, with the research team comprising Prof. Ankona Datta and Sujit Das from the Tata Institute of Fundamental Research, Mumbai, and Heqi Xi, Itsuki Yamamoto, and Prof. Katsumasa Fujita from the University of Osaka, Japan.

An international group of experts has developed new guidelines to help veterinarians better recognize and diagnose canine cognitive dysfunction syndrome (CCDS), commonly known as canine dementia. The condition affects many older dogs and can cause changes in behavior, sleep, learning, and daily routines, yet it is often overlooked despite its significant impact on animal welfare. The guidelines also highlight that research on canine dementia has the potential to contribute to our understanding of human dementia, particularly Alzheimer’s disease.

Why some memories persist while others vanish has fascinated scientists for more than a century. Now, new research from the Stowers Institute has identified the mechanism that makes a fleeting moment unforgettable. In a study that culminates more than 20 years of work, Stowers scientists have provided the first direct evidence that the nervous system can deliberately form amyloids to help turn sensory experiences into lasting memories. The research forces us to rethink long-standing assumptions about memory and the consequence of amyloid formation in the brain, potentially providing new avenues for treating amyloid-related disorders of the nervous system.

In research that could shed light on the growth and formation of complex tissue architectures, Brown University engineers show how cells orbit and reconfigure their surroundings to venture outward from confined spheroids.