Drugs to treat inflammatory and autoimmune diseases — such as asthma, psoriasis, rheumatoid arthritis or Chrousos syndrome — act mainly through the glucocorticoid receptor (GR). This essential protein regulates vital processes in various tissues, so understanding its structure and function at the molecular level is essential for designing more effective and safer drugs. Now, a study published in the journal Nucleic Acids Research (NAR) has revealed the mechanism of multimerization — the association of different molecules to form complex structures — of the glucocorticoid receptor, a process critical to its physiological function.

This study obtained historical genomes (~1900) of 46 Eastern honeybees. A comparison between historical and contemporary genomes revealed a decline in genetic diversity. Genes related to the nervous system have undergone rapid evolution over the past century, including key insecticide targets nAchRs. Insecticide exposure experiments confirmed genomic divergence among populations: those from central China exhibited stronger pesticide tolerance compared to populations from Malaysia.

For decades, scientists have known that bacteria can exchange genetic material in a process called horizontal gene transfer. Research by Professor Mittra’s group suggests that horizontal transfer also happens in mammals via fragments of DNA known as cell-free chromatin particles that are released from dying cells. Once inside new host cells, the chromatin particles acquire novel functions and act as autonomous “satellite” genomes. This discovery may redefine mammalian genomics and evolution.

Egyptian paleontologists have discovered the earliest known member of Dyrosauridae — a group of long-snouted, coastal and marine Crocodyliforms— in the Western Desert of Egypt. The new species, Wadisuchus kassabi, lived around 80 million years ago and bridges a crucial fossil gap in the early evolution of marine crocs. The well-preserved skull and jaws, described in The Zoological Journal of the Linnean Society, reveal transitional features in the development of the dyrosaurid snout and skull adaptations. The findings point to North Africa — particularly Egypt’s Quseir Formation — as the birthplace of Dyrosauridae before their global expansion following the dinosaur extinction.

Researchers at The University of Osaka and The University of Tokyo developed a photoactivatable alkyne tag that enables stable, selective visualization of biomolecules inside living cells. The technology would contribute to reveal previously unseen molecular communication, paving the way for advances in cell biology and drug discovery.

The henna tree is commonly used for making henna dye. Now, a new study suggests that the same pigments that change your skin or hair that distinctive orange-red color could be used for another purpose: treating liver disease.