21-Oct-2025
When cells run a red light: Double trouble for old models in cell division
Ruđer Bošković InstitutePeer-Reviewed Publication
Croatian scientists have rewritten a 20-year story of how cells divide. At the Ruđer Bošković Institute in Zagreb, Croatia, Dr Kruno Vukušić and Professor Iva Tolić, a group leader and two-time ERC grantee, show that the protein CENP-E, long believed to act as a motor dragging chromosomes into place during cell division, in fact plays a completely different role in chromosome movement. It stabilizes the first attachments of chromosomes to the cell’s internal “tracks,” ensuring they line up correctly before being divided. The group also found a mechanism involving centrosomes that spatially regulates the activity of major chromosome machinery, linking the signaling of two key mitotic structures. Findings overturn two decades of textbook understanding and carry major implications for life sciences, since errors in this process underline many cancers and genetic diseases.
- Journal
- Nature Communications
- Funder
- European Research Council, European Regional Development Fund, European Regional Development Fund, The Croatian Science Foundation