Scientists have developed a highly sensitive single-cell tool that can help uncover links to complex diseases. Known as single-cell DNA-RNA-sequencing (SDR-seq), this tool created by scientists from EMBL's Genome Biology Unit can study both DNA and RNA simultaneously inside the same cell – a critical element in understanding how genetic variants impact gene expression in what’s called the non-coding region of the genome.

With SDR-seq, the scientists found that even small changes in DNA can change how genes are regulated in stem cells, and in a type of blood cancer called B-cell lymphoma.   

SDR-seq offers genome biologists scale, precision, and speed to help understand and eventually treat a broad range of diseases.

BUFFALO, NY — October 10, 2025 — A new research paper was published in Volume 12 of Oncoscience on September 30, 2025, titled “Lifestyle and hormonal factors affecting semen quality and sperm DNA integrity: A cross-sectional study.”

Microscopic organisms that regulate Earth’s climate and sustain ocean ecosystems take centre stage in a new awareness campaign. Five European research organisations propose 10 October as International Coccolithophore Day, highlighting the calcite-plated plankton that drive the ocean's carbon cycle, shape the climate, and support food webs. Their plates sink to archive climate history, while European projects track how warming, acidification, and ecology affect carbon storage.

Researchers at University of Tsukuba have developed DeMemSeg, an AI-powered analysis pipeline that addresses a long-standing challenge in microscopy: precisely segmenting and measuring individual cell membranes that overlap in two-dimensional (2D) projection images. This innovation is expected to accelerate research on cellular mechanisms and related diseases.

Researchers have found that low to moderate-severity fires not only benefit many bird species in the Sierra Nevada, but these benefits may persist for decades. In addition to a handful of bird species already known to be “post-fire specialists”, a broad variety of other more generalist species, like Dark-eyed Juncos and Mountain Chickadees, clearly benefited from wildfire. This research will help land managers make decisions about how to manage forests and fires as they face a changing fire regime.

The Brain & Behavior Research Foundation (BBRF), the world’s largest private funder of mental health research grants, announced it is awarding the 2025 Outstanding Achievement Prizes in Mental Health to five scientists for their exceptional contributions to psychiatric research.