Molecular glue discovery: large scale instead of lucky strike
CeMM Research Center for Molecular Medicine of the Austrian Academy of SciencesPeer-Reviewed Publication
Many diseases are driven by proteins that are difficult or impossible to inhibit with conventional drugs. Instead of blocking their activity, an emerging therapeutic strategy aims to remove these proteins entirely from the cell by harnessing the cell’s own degradation machinery. In a new study, researchers at CeMM, AITHYRA and the Scripps Research Institute have now developed a systematic method to discover such protein-degrading compounds on a large scale. The approach, published in Nature Chemical Biology (DOI: 10.1038/s41589-025-02137-2) provides a powerful new route toward therapies for diseases such as certain aggressive forms of leukemia.Many diseases are driven by proteins that are difficult or impossible to inhibit with conventional drugs. Instead of blocking their activity, an emerging therapeutic strategy aims to remove these proteins entirely from the cell by harnessing the cell’s own degradation machinery. In a new study, researchers at CeMM, AITHYRA and the Scripps Research Institute have now developed a systematic method to discover such protein-degrading compounds on a large scale. The approach, published in Nature Chemical Biology (DOI: 10.1038/s41589-025-02137-2) provides a powerful new route toward therapies for diseases such as certain aggressive forms of leukemia.
- Journal
- Nature Chemical Biology