Therapeutic targeting of the AhR-Siglec-15 axis reveals potent efficacy against SHH medulloblastoma in preclinical models.

A flow cytometry-based approach to isolate extracellular vesicles is evaluated and its impact on microRNA cargo is revealed, showing reduced molecular diversity while preserving core functional signals relevant to tissue repair and inflammation.

Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality, with significant residual risk unexplained by traditional factors. The discovery of novel therapeutic targets or the repurposing of existing drug targets could improve the prevention and treatment for different CVDs. However, previous studies have encountered different analytic challenges, such as failing to cover the whole spectrum of CVDs, not including cardiovascular magnetic resonance imaging (CMR) traits or lack of large-scale replication analysis and multidimensional downstream analysis.

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at the base of crypts. While ISCs play an essential role in epithelial regeneration following injury, such as that induced by chemotherapy or radiation, the underlying regulatory mechanisms remain incompletely understood.

The liver plays a central role in maintaining systemic energy homeostasis during fasting by mobilizing lipid reserves, a process often accompanied by transient hepatic steatosis. Dimethylarginine dimethylaminohydrolase 1 (DDAH1), a key enzyme metabolizing asymmetric dimethylarginine (ADMA), has been shown to protect against NAFLD under nutrient-overload conditions. However, its role in the physiological context of fasting remained elusive.

During 2026, new legislation – the result of an agreement between the UK Government and the European Union – is planned to come into force for recreational pollack fishing that limits catches to three fish per angler per day. It will result in more fish being released after they are caught, but new research led by the University of Plymouth (UK) - and involving scientists and industry representatives across the UK - has suggested changing how that release happens could have a marked difference on the fisheries’ long-term sustainability.

Matthew Troia, a UT San Antonio assistant professor, was awareded the distinguished Faculty Early Career Development Program (CAREER) award by the National Science Foundation. The award will support his investigation on how climate change and urbanization are affecting freshwater ecosystems by enabling exotic tropical fish species to expand northward. During the next five years, Troia will integrate lab experiments, extensive field monitoring, and computer modeling to better understand the vulnerability of Texas waterways.

New research following US adolescents ages 11–12 shows that problematic use of mobile phones, social media, and video games was associated with higher risks of mental health problems, sleep disturbance, and suicidal behaviors one year later. The study in the American Journal of Preventive Medicine, published by Elsevier, reveals that the links between problematic screen use and mental health are stronger than those previously reported for overall screen time and highlights the risks of addictive use.

Modern-day African softshell turtles have less diverse diets than their ancient counterparts, with human-driven agriculture and carrion likely shaping their change in foraging