Researchers at McGill University and the United States Forest Service have found that plants living in areas where human activity has caused population crashes carry long-lasting genetic traces of that history, such as reduced genetic diversity. Because genetic diversity helps species adapt to climate change, disease and other stresses, the study suggests it is vital to consider a population’s history-influenced genetics alongside its size and habitat in conservation planning.

The most effective conservation strategies for protecting vertebrates on a global scale are those aimed at mitigating the effects of overexploitation, habitat loss and climate change, which are the most widespread threats with the greatest impact across the planet. This is one of the main conclusions of an article led by researchers Pol Capdevila, from the Faculty of Biology and the Biodiversity Research Institute (IRBio) at the University of Barcelona, and Duncan O’Brien, from the University of Bristol (United Kingdom).

As part of a new study researchers from Bournemouth University (BU) have discovered European eels, Anguilla anguilla, at the stage of silvering living in the inland waters of Cyprus for the first time.

A recent study published in Science China Life Sciences demonstrates that disulfiram, a drug used to treat alcoholism, can suppress liver cancer by regulating lipid metabolism and angiogenesis. Researchers found that disulfiram upregulates the gene c-FOS by reducing its RNA methylation, which in turn inhibits key molecules involved in lipid accumulation and blood vessel formation in tumors. This discovery highlights a promising repurposing potential for disulfiram in hepatocellular carcinoma therapy.

Therapeutic targeting of the AhR-Siglec-15 axis reveals potent efficacy against SHH medulloblastoma in preclinical models.

A flow cytometry-based approach to isolate extracellular vesicles is evaluated and its impact on microRNA cargo is revealed, showing reduced molecular diversity while preserving core functional signals relevant to tissue repair and inflammation.

Cardiovascular diseases (CVDs) remain a leading cause of global morbidity and mortality, with significant residual risk unexplained by traditional factors. The discovery of novel therapeutic targets or the repurposing of existing drug targets could improve the prevention and treatment for different CVDs. However, previous studies have encountered different analytic challenges, such as failing to cover the whole spectrum of CVDs, not including cardiovascular magnetic resonance imaging (CMR) traits or lack of large-scale replication analysis and multidimensional downstream analysis.