The GCAT team at IGTP has developed PolyGenie, a new open tool that enables researchers to explore and reuse genomic data more easily. Designed to support large-scale genetic association studies, the platform advances GCAT's commitment to FAIR data and Open Science. Its development and application to the GCAT cohort are described in NAR Genomics and Bioinformatics.

MD4SB will establish an infrastructure for the dynamic description of biological macromolecules, connecting three major European Research Infrastructures (Instruct-ERIC, ELIXIR, and EU-OPENSCREEN ERIC) with three of Europe's largest supercomputing centres (BSC-CNS, CINECA, and JSC).

The project will facilitate the use of molecular simulations to understand how biomacromolecules function, advance the molecular description of diseases, and accelerate drug discovery.

Coordinated by IRB Barcelona, the project brings together 25 partners across 8 countries and incorporates Almirall, Sanofi, and other pharmaceutical companies to provide feedback and evaluate the practical usefulness of the platform in industrial settings. The IRB Barcelona spin-off company Nostrum Biodiscovery will bridge the gap between academic groups and pharmaceutical companies.

Conventional methods generally analyze many proteins simultaneously. The specific traits of individual protein molecules are thus often unclear. A research team led by Dr. Sarina Veit and Professor Thomas Günther-Pomorski at Ruhr University Bochum, Germany, in collaboration with researchers from Weill Cornell Medicine in New York and the University of Toronto, Canada, has developed a new microscopy platform that overcomes this limitation. The method allows the simultaneous examination of hundreds of tiny membrane spheres each with a diameter of only about 200 nanometers. Each of these synthetic membrane spheres contains just one lipid transport protein. Using this method, the researchers can conduct measurements at the level of individual protein molecules. At the same time, the platform is flexible enough to be used to examine other proteins as well. The researchers report their results in the journal Nature Structural & Molecular Biology from June 15, 2026.

Researchers studied the microbes associated with historical middens conserved in Greenland’s permafrost, left behind by Paleo-Inuit, ancient Norse, and early modern Inuit. These middens harbored biodiverse bacterial communities – including many unknown taxa – that were especially rich in human- and animal-associated groups. The authors concluded that microbial traces of human activities such as defecation, livestock farming, and seal hunting can linger for centuries in Arctic middens. They also found a wide range of antimicrobial resistance genes in the bacterial genomes. However, the limited outward spread of potential pathogens away from the frozen core of the middens means that they currently pose little risk to public health.  

Researchers from The University of Osaka found that using a sequence analysis approach that incorporates awareness of insertions and deletions in extramembrane domains enabled accurate reconstruction of ancestral rhodopsins that folded correctly and functioned as predicted when expressed in E. coli. The researchers’ ConsistASR analytical pipeline could be used to engineer other ancestral proteins in the future.

Genome sequencing has revealed insights into how current-day residents of the Faroe Islands can trace their ancestry to a North Atlantic founder population and how evolutionary forces have shaped their genomes since.

UC San Diego biologists have uncovered new details about barrier-forming cells that protect and nourish the brain. Their findings focused on senescent cells, which traditionally have been labelled as “zombie” cells, and their formative role in the developing brain and beyond.