Rivals or allies – how do bacteria and fungi interact in our bodies? Until now, bacteria on our mucous membranes were primarily considered to be antagonists of fungi, as they can inhibit their growth. However, an international research team led by the Leibniz-Institute for Natural Product Research and Infection Biology (Leibniz-HKI) in Jena has now been able to show that the yeast Candida albicans and the bacterium Enterococcus faecalis form a dangerous alliance under certain conditions: Instead of fighting each other, they can amplify their impact and cause significantly more severe cell damage together than alone. In the study now published in the journal PNAS, the researchers reveal the mechanisms behind this – and the crucial role of the bacterial toxin cytolysin.

A new study reveals a clear conclusion: strength (resistance) training is the most effective tool for achieving “high-quality” weight loss, reducing body fat while preserving, and even increasing, muscle mass.

Researchers in China identified Fusarium cugenangense as a novel causal agent of pear wilt in China. Systemic infection is demonstrated via GFP-labeling and ultrastructural analysis. This is the first report of F. cugenangense causing pear wilt disease in China.

PCP binds to TLR5, activating the TLR signaling pathway, which triggers inflammation, oxidative stress, disrupted amino acid metabolism, and liver damage, ultimately compromising immune function.

Ovarian cancer kills more women than any other gynecological cancer. Most patients receive their diagnosis only after the disease spreads throughout the abdomen. Until now, scientists have never fully understood why this cancer advances so fast. A new study led by Nagoya University explains why. Published in Science Advances, the study shows that cancer cells recruit help from protective mesothelial cells that normally line the abdominal cavity. Mesothelial cells lead the invasion and cancer cells follow the pathways they create. These hybrid cell clusters resist chemotherapy better than cancer alone.