A single starting point for different cancers
Peer-Reviewed Publication
Updates every hour. Last Updated: 26-Oct-2026 10:16 ET (26-Oct-2026 14:16 GMT/UTC)
How do different cancer subtypes arise? Do they originate from distinct cells, or from a single multipotent cell capable of differentiating into multiple cell types? This question, debated for decades in cancer biology, is now gaining new insight thanks to the work of the Laboratory of Experimental Pathology (ULiège), in collaboration with researchers from Université Paris Cité and Sorbonne University.
Breast cancer can remain dormant in the bone marrow for decades before reactivating, resulting in cancer relapse. A study published in Bone Research unveils the critical role of Notch2 signaling pathway in promoting this dormant state. The study explains how dormant cancer cells mimic healthy stem cells and activate stress pathways to survive in the bone marrow—paving the way for innovative targeted therapies against dormant cancer cells.
CardioNVT is an end-to-end deep learning platform for rapid, immunostaining-free assessment of cardiomyocyte nuclear ploidy in situ. Using only DAPI-stained heart sections, it segments cardiomyocyte nuclei, tracks them across z-stack planes, reconstructs 3D nuclear volumes, and infers ploidy from volume measurements, enabling scalable studies of cardiac development, remodeling, and repair.