Life begins with a single fertilized cell that gradually transforms into a multicellular organism. This process requires precise coordination; otherwise, the embryo could develop serious complications. Scientists at ISTA have now demonstrated that the zebrafish eggs, in particular their curvature, might be the instruction manual that keeps cell division on schedule and activates the appropriate genes in a patterned manner to direct correct cell fate acquisition. These insights, published in Nature Physics, could help improve the accuracy of embryo assessments in IVF.

An international study published in the Journal of Environmental Management uses nearly two decades of data to examine wolf–human interactions across Türkiye. Co-authored by Prof. Dr. Çağan H. Şekercioğlu of Koç University and the University of Utah, the research shows that conflicts are not random but follow predictable spatial and seasonal patterns. The findings point to risk mapping and community-based strategies as key tools for supporting coexistence between wildlife conservation and rural livelihoods.

This study reveals how lipid metabolism dysregulation promotes colorectal cancer liver metastasis (CRLM) through a novel YTHDF3-mediated mechanism involving m⁶A RNA modification and liquid-liquid phase separation.

Though it has long been recognized that the liver exhibits remarkable immune tolerance, the underlying mechanisms driving this phenomenon remain poorly understood. Here, we explore the liver’s unique immune tolerance—a critical feature that enables it to process gut- and diet-derived inflammogens without eliciting excessive inflammation. We propose that entero-pancreatic peptide hormones (e.g., GLP-1, GIP, CCK, glucagon, VIP, amylin) and postprandially reabsorbed bile acids (BAs), delivered at high concentrations via the portal vein, activate G protein-coupled receptors and trigger cAMP signalling pathways that ultimately promote anti-inflammatory responses through mechanisms such as PKA–CREB and Epac activation. These pathways have been implicated in suppressing inflammation, and fostering a tolerogenic phenotype in resident immune cells.

Lymphatic malformations (LMs) are congenital vascular anomalies characterized by abnormal lymphatic development, leading to disfigurement and severe clinical complications. However, the immunopathological mechanisms underlying LMs remain poorly defined. Here, we provide a comprehensive single-cell immune landscape of LMs by integrating single-cell RNA, T-cell receptor, and B-cell receptor sequencing (scRNA-seq, scTCR-seq, and scBCR-seq) on peripheral blood and pleural effusion samples, uncovering profound immune dysregulation and chronic inflammation.

The intestinal epithelium undergoes rapid renewal every 3–5 days, a process driven by intestinal stem cells (ISCs) located at the base of crypts. While ISCs play an essential role in epithelial regeneration following injury, such as that induced by chemotherapy or radiation, the underlying regulatory mechanisms remain incompletely understood.

In recent decades, scientists have debated whether a seven-million-year-old fossil was bipedal—a trait that would make it the oldest human ancestor. A new analysis by a team of anthropologists offers powerful evidence that Sahelanthropus tchadensis—a species discovered in the early 2000s—was indeed bipedal by uncovering a feature found only in bipedal hominins.