The countries participating in the UN Climate Change Conference (COP30), currently taking place in Brazil, must cancel fossil fuel concessions in order to keep the Paris Agreement alive. This is the main message of a paper published in the journal Nature and signed by experts Martí Orta, Gorka Muñoa and Marcel Llavero, from the Faculty of Biology and the Biodiversity Research Institute (IRBio) of the University of Barcelona, and Guillem Rius, from the Barcelona Institute for Global Health (ISGlobal).

Varicella-zoster virus (VZV) is a highly contagious human herpesvirus responsible for chickenpox upon primary infection and shingles upon viral reactivation. While Varicella-zoster immune globulin (VZIG) can offer post-exposure protection for high-risk individuals, structural insights into neutralizing antibodies (nAbs) derived from natural infection remain limited. Glycoprotein E (gE), the most abundant and immunogenic envelope protein of VZV, plays an essential role in viral infection and is the sole antigen in the recombinant zoster vaccine.

Cervical cancer will be the first human cancer eliminated through coordinated global action. A new special issue of Cancer Biology & Medicine brings together leading experts from around the world to examine progress, challenges, and innovations in prevention, screening, and treatment. 

Ischemic stroke is a complex cerebrovascular disorder characterized by highly unpredictable outcomes influenced by patient-specific variables, including age, stroke severity, and preventable stroke-related complications such as infections. Analyses of clinical data have indicated a cumulative post-stroke infection rate of approximately 30%, with reported rates ranging from 5% to 65%. Post-stroke infections pose a significant challenge, as they not only increase the financial burden of stroke care but are also associated with adverse clinical outcomes, prolonged hospital stays, and a higher risk of stroke recurrence. The inflammatory response plays a pivotal role in the pathophysiology of ischemic stroke, encompassing the activation of inflammatory cells, the release of inflammatory mediators, and the engagement of inflammatory signaling pathways. Recent advances in molecular biology have facilitated the identification and investigation of numerous inflammation-related biomarkers. This article reviews the roles and mechanisms of key inflammatory biomarkers, including cytokines, chemokines, adhesion molecules, inflammation-related enzymes and mediators, receptors, signaling pathway molecules, and acute-phase proteins in the context of ischemic stroke, highlighting their significance in stroke pathophysiology and prognostic assessment. Additionally, in conjunction with the latest research advances, the article discusses novel biomarkers such as microRNAs and galectin-3, which are emerging as important tools in multiple domains, including diagnosis and treatment. Drawing on clinical diagnostic and therapeutic practices, this review analyzes the diagnostic and therapeutic roles of both novel and traditional biomarkers in the progression of ischemic stroke, following the temporal sequence from disease onset to prognosis. Finally, the article addresses the limitations of current research and offers perspectives on future directions, providing insights that may contribute to the advancement of precision medicine in the management of ischemic stroke.