The eye is a highly specialized optical and mechanical system whose structural integrity and visual performance rely heavily on the precise arrangement of the extracellular matrix (ECM). As the primary structural protein of the ocular ECM, collagen provides not only physical support through its hierarchical self-assembled structure but also regulates cellular behavior via bioactive sequences. However, bridging the gap from natural tissues to synthetic biological scaffolds to achieve precise emulation of the complex microenvironments in the cornea, sclera, and retina remains a core challenge in ocular tissue engineering.  The review article titled "Ocular collagen: From architecture to biomaterials," published in Eye Discovery (2026) by researchers from East China University of Science and Technology, systematically evaluates the distribution logic of collagen across various ocular tissues. It discusses cutting-edge progress in constructing high-performance ophthalmic repair materials using physical, chemical, and biological methodologies.

In the deserts of southeastern Arizona, harvester ants congregate with serrated jaws agape outside the nests of much smaller cone ants. However, the nests’ inhabitants are not threatened. Instead, they crawl all over the harvester ants and lick and nibble their body surfaces—the first known example of an ant that cleans a much larger ant species. The unusual behavior, described for the first time this week in the journal Ecology and Evolution, was observed by entomologist Mark Moffett, a research associate at the Smithsonian's National Museum of Natural History.

A team of Weill Cornell Medicine investigators is working to cross-train the next generation of cancer researchers in cancer biology and the use of artificial intelligence tools for research.

Vaccines rely on adjuvants to enhance immune protection, but these often cause reactogenicity, such as swelling or fever. Challenging the long-held assumption that these effects are inseparable, researchers from Japan have shown that vaccine efficacy and reactogenicity are driven by distinct immune pathways. Their findings reveal specific roles for IL-1α and IL-1β in controlling these responses, opening new possibilities for designing vaccines that maintain strong immunity while minimizing adverse effects.

With the rapid development of single-cell RNA sequencing (scRNA-seq), researchers can now examine gene activity in individual plant cells at unprecedented resolution, opening new opportunities to study cell differentiation, tissue development, and stress responses. However, scRNA-seq datasets compile data from thousands of cells and are characterized by high dimensionality, extreme sparsity, and substantial technical noise. Notably, most of the genes expressed in a given cell are expressed in every type of cell; only a relatively small number of genes, so-called marker genes, are specific to each cell type. Consequently, the task of assigning roles to individual cells relies heavily on prior knowledge of the biological context and which genes are highly expressed in each cell type — making it difficult to identify marker genes and assign cell types accurately.