Doxorubicin (DOX) is widely used to treat cancer but can cause severe heart damage. In a recent study, researchers from China identified glutathione S-transferase P1 (GSTP1) as a crucial protective factor against DOX-induced cardiomyopathy. They revealed that GSTP1 suppresses acyl-CoA synthetase long-chain family member 4 (ACSL4)-dependent ferroptosis through the JNK signaling pathway, reducing oxidative stress and highlighting GSTP1 as a promising therapeutic target for preventing DOX-related heart injury.

New study combines a novel approach using patterned optogenetics with electrophysiology, circuit mapping, and computational modelling to uncover how ancient brain circuits filter and prioritise visual information.

The study showcases an innovative and effective approach for large-scale genomic research of individual cells and viral particles, highlighting the abundance of marine viruses with unusual DNA chemistry.