Dynamic switching between revival stem cells and conventional intestinal stem cells enables efficient tissue repair without exhausting the stem cell pool, report researchers from Institute of Science Tokyo. Using organoid and mouse disease models, the researchers uncovered how flexible stress-tolerant cell states contribute to intestinal repair—providing a better understanding of the biological mechanisms driving intestinal regeneration.

Researchers induced haploid zebrafish using UV-treated sperm and tracked why the embryos developed severe defects. They found that haploid embryos had low gastrulation and hatching rates, widespread malformations, and major changes in gene activity. The study points to disrupted FGF/Wnt signaling, mitochondrial function, ion transport, and cell-cycle control as key drivers of the lethal "haploid syndrome."

Salk scientists Gerald Shadel and Tatyana Sharpee elected as American Association for the Advancement of Science (AAAS) 2025 Fellows. AAAS Fellows are distinguished scientists, engineers, and innovators who have made significant contributions to their fields.

When the “eco-friendly” bioplastic, polylactic acid (PLA), biodegrades, the resulting nanoplastics can accumulate in the fetuses of pregnant mice and interfere with fetal growth. Yichao Huang and De-Xiang Xu of Anhui Medical University, China, and Mingliang Fang of Fudan University, China, report these findings in a new study published March 26^th in the open-access journal PLOS Biology.