Achieving cross-coupling reactions of fatty amide reduction radicals via iridium-photorelay catalysis and other strategies
Peer-Reviewed Publication
Updates every hour. Last Updated: 10-May-2026 09:15 ET (10-May-2026 13:15 GMT/UTC)
Professor Pei-Qiang Huang's research group at Xiamen University recently reported the first reduction-cross-coupling reaction of aliphatic tertiary amides with 4-cyanopyridine via iridium and photoredox tandem catalysis. This method is based on the formation of imineonium through iridium-catalyzed hydrosilylation and acid catalysis, followed by tandem photocatalysis to generate two radicals (C,N,N trialkyl α-amino radical and stable 4-cyano-1,4-dihydropyridine radical) which then undergo a cross-coupling reaction. The reaction exhibits excellent chemoselectivity, enabling gram-scale reactions with extremely low catalyst loadings, and the products can be converted in one step to partially and fully saturated α-nitrogen-substituted amines. These characteristics make this method promising for applications in organic synthesis, natural products, and pharmaceuticals. The article was published as an open access Research Article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.
A new forecasting system developed in collaboration between the University of Helsinki and CMCC delivers detailed 15-day Mediterranean Sea predictions in just 20 seconds. By combining machine learning, ocean physics, and atmospheric data, SeaCast is faster than traditional numerical forecasts and more accurate than traditional physical models, achieving high-resolution predictions that represent a big advancement in marine forecasting. Published in Nature – Scientific Reports, this research opens new horizons for understanding, preparing for, and responding to the challenges and opportunities of the Mediterranean region.
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