Breakthrough in deep tissue super-resolution imaging via confocal² spinning-disk ISM
Peer-Reviewed Publication
Updates every hour. Last Updated: 8-Nov-2025 17:11 ET (8-Nov-2025 22:11 GMT/UTC)
To address fidelity loss in deep-tissue imaging, Prof. Peng Xi’s team at Peking University developed Confocal² Spinning-Disk Image Scanning Microscopy (C²SD-ISM). By combining spinning-disk confocal microscopy with structured illumination, C²SD-ISM achieves high-fidelity 3D imaging up to 180 μm deep, with 144 nm lateral and 351 nm axial resolution, and retains up to 92% correlation with original confocal images.
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