Enantioselective synthesis of polycyclic aromatic tetralinyl lignans based on symmetry-directed strategy
Peer-Reviewed Publication
Updates every hour. Last Updated: 21-Oct-2025 08:11 ET (21-Oct-2025 12:11 GMT/UTC)
Based on a symmetry-guided synthesis strategy, the research group of Professor Yefeng Tang at Tsinghua University recently achieved the efficient construction of the tricyclic core skeleton of polycyclic aromatic tetralin-type lignans by using as key steps the chiral phosphoric acid-catalyzed photoasymmetric [2+2] cycloaddition and ring strain-driven oxidative ring expansion reactions. They also achieved the efficient enantioselective total synthesis of multiple aromatic tetralin-type lignan natural products through subsequent biomimetic cyclization and local desymmetrization reactions. These results were published as an open access article in CCS Chemistry, the flagship journal of the Chinese Chemical Society.
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