Unified LSCI–IPPG converge on intraoperative cerebral perfusion
Peer-Reviewed Publication
Updates every hour. Last Updated: 4-May-2026 01:15 ET (4-May-2026 05:15 GMT/UTC)
Despite the long-standing reputation of each, as well as distinct underlying physics, laser speckle contrast imaging (LSCI) and imaging photoplethysmography (IPPG) reach concordance on functional cerebral haemodynamics. The unified, heartbeat-resolved, camera-based readout offers fast, wide-field assessment of cortical perfusion for the operating theatre.
In the field of polyoxometalate chemistry, organophosphonate covalently modified polyoxometalates have recently emerged as a promising frontier. These hybrid materials not only broaden the structural diversity of conventional polyoxometalate derivatives and address the inherent stability limitations of polyoxometalates, but also allow for the design of improved properties tailored to diverse applications. This review provides a comprehensive summary of recent advances in organophosphonate covalently modified polyoxometalates research, with a particular focus on their structural features, functional properties, and prospective research directions.
Polyoxometalates are promising inorganic drugs with antiviral activity; however, they pose a risk to humans because of their potential accumulation in the body. Polyoxometalates encapsulated with berberine from a traditional Chinese herb may exhibit lower cytotoxicity. In this study, the antiviral effects of four berberine-based organic–polyoxometalate hybrids (BR-POMs) on BHK-21 and PK-15 cells were evaluated in vitro using encephalomyocarditis virus (EMCV) or pseudorabies virus (PRV) models. The collected cells were used for quantitative polymerase chain reaction analysis. The supernatants were collected to quantify the viral loads using a TCID50 assay in vitro. EC50 and CC50 were determined through dose–response experiments, and the EC50/CC50 ratio was used as a selectivity index to measure the antiviral activity. The results demonstrate that all BR-POMs exhibited certain antiviral activity. The BR-POMs did not exert toxicity against the EMCV- or PRV-infected cells at the tested concentration (CC50 > 40 μM). Notably, BR-EuSiW (EC50 15.07 μM, CC50 651.2 µM, SI 43.21) exerted antiviral effects by acting on the virus at its biosynthesis stage, thereby inhibiting virus proliferation in a dose-dependent manner. This study demonstrates that organic–polyoxometalate hybrids represent a new strategy for developing antivirals against EMCV.
The ability to generate and detect ultrashort light pulses in the ultraviolet UV-C range (100-280 nm) is crucial for many applications. This work demonstrates a UV-C source-sensor platform that combines nonlinear optical crystals for the generation of femtosecond UV-C laser pulses with photodetectors based on atomically-thin semiconductors. The platform has potential for different technologies, from broad-band imaging to spectroscopy on femtosecond timescales. As a proof of concept, the source-sensor is used to demonstrate free-space communication.