5-Jun-2026
Mineralized DNA scaffold boosts bone repair by reprogramming immune cells
Editorial Office of West China School of Stomatology, Sichuan UniversityPeer-Reviewed Publication
A new study developed a mineralized DNA hydrogel that combines immune regulation with sustained bone regeneration. Using tetrahedral DNA nanostructures and calcium phosphate mineralization, researchers created a scaffold that promotes healing-friendly macrophage activity while supporting bone-forming stem cells. In animal models, the material accelerated bone repair, improved tissue mineralization, and prolonged structural stability. The findings may advance next-generation biomaterials for craniofacial reconstruction, traumatic injuries, and challenging bone healing disorders worldwide.
- Journal
- Bone Research
- Funder
- National Natural Science Foundation of China, Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China, Young Elite Scientists Sponsorship Program by CAST (, Major Science and Technology Special Project of Sichuan Province, Leading Scientist Program for Basic Research of Sichuan Province, The Sichuan Science and Technology Program, Sichuan Province Youth Science and Technology Innovation Team, Health Commission of Sichuan Province Medical Science and Technology Program, Research and Develop Program, the West China Hospital of Stomatology Sichuan University